Potential chemopreventive activities of a polyphenol rich purified extract from olive mill wastewater on colon cancer cells

Barbara Bassani, Teresa Rossi, Daniela De Stefano, Daniele Pizzichini, Paola Corradino, Nicoletta Macrì, Douglas M. Noonan, Adriana Albini, Antonino Bruno

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Olive oil, a major feature of the Mediterranean diet, is an abundant source of phenolic compounds. Olive oil production is associated with the generation of waste material, termed ‘olive mill wastewater’ (OMWW), that has been reported to be enriched in soluble polyphenols. Given the known beneficial activity of polyphenols, we investigated whether the use of purified extracts from OMWW, termed A009, rich in hydroxytyrosol, might have anticancer activities on colon cancer (CC) cell lines in vitro and in vivo and could represent a chemopreventive preparation for CC. A009 from different batches inhibited proliferation, migration, invasion, adhesion, sprouting of CC cells and release of angiogenic, pro-inflammatory cytokines (VEGF, IL-8). Our data demonstrate that a novel purified, polyphenol enriched extract, obtained from food industry waste material, with similar activity than purified hydroxytyrosol but easier to produce in large quantities and with an environment-sensitive approach, has potential cancer chemopreventive properties for colon cancer cells.

Original languageEnglish
Pages (from-to)236-248
Number of pages13
JournalJournal of Functional Foods
Volume27
DOIs
Publication statusPublished - Dec 1 2016

Fingerprint

Polyphenols
Olea
Waste Water
colorectal neoplasms
Colonic Neoplasms
wastewater
polyphenols
extracts
olive oil
Mediterranean Diet
Mediterranean diet
Food Industry
interleukin-8
sprouting
Interleukin-8
Vascular Endothelial Growth Factor A
adhesion
food industry
phenolic compounds
cytokines

Keywords

  • Chemoprevention
  • Colon cancer
  • Hydroxytyrosol
  • Olive mill wastewater
  • Polyphenols

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science
  • Nutrition and Dietetics

Cite this

Potential chemopreventive activities of a polyphenol rich purified extract from olive mill wastewater on colon cancer cells. / Bassani, Barbara; Rossi, Teresa; De Stefano, Daniela; Pizzichini, Daniele; Corradino, Paola; Macrì, Nicoletta; Noonan, Douglas M.; Albini, Adriana; Bruno, Antonino.

In: Journal of Functional Foods, Vol. 27, 01.12.2016, p. 236-248.

Research output: Contribution to journalArticle

@article{c5bd252f3ffa4a0ab55b6aaa1c5d09d5,
title = "Potential chemopreventive activities of a polyphenol rich purified extract from olive mill wastewater on colon cancer cells",
abstract = "Olive oil, a major feature of the Mediterranean diet, is an abundant source of phenolic compounds. Olive oil production is associated with the generation of waste material, termed ‘olive mill wastewater’ (OMWW), that has been reported to be enriched in soluble polyphenols. Given the known beneficial activity of polyphenols, we investigated whether the use of purified extracts from OMWW, termed A009, rich in hydroxytyrosol, might have anticancer activities on colon cancer (CC) cell lines in vitro and in vivo and could represent a chemopreventive preparation for CC. A009 from different batches inhibited proliferation, migration, invasion, adhesion, sprouting of CC cells and release of angiogenic, pro-inflammatory cytokines (VEGF, IL-8). Our data demonstrate that a novel purified, polyphenol enriched extract, obtained from food industry waste material, with similar activity than purified hydroxytyrosol but easier to produce in large quantities and with an environment-sensitive approach, has potential cancer chemopreventive properties for colon cancer cells.",
keywords = "Chemoprevention, Colon cancer, Hydroxytyrosol, Olive mill wastewater, Polyphenols",
author = "Barbara Bassani and Teresa Rossi and {De Stefano}, Daniela and Daniele Pizzichini and Paola Corradino and Nicoletta Macr{\`i} and Noonan, {Douglas M.} and Adriana Albini and Antonino Bruno",
year = "2016",
month = "12",
day = "1",
doi = "10.1016/j.jff.2016.09.009",
language = "English",
volume = "27",
pages = "236--248",
journal = "Journal of Functional Foods",
issn = "1756-4646",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Potential chemopreventive activities of a polyphenol rich purified extract from olive mill wastewater on colon cancer cells

AU - Bassani, Barbara

AU - Rossi, Teresa

AU - De Stefano, Daniela

AU - Pizzichini, Daniele

AU - Corradino, Paola

AU - Macrì, Nicoletta

AU - Noonan, Douglas M.

AU - Albini, Adriana

AU - Bruno, Antonino

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Olive oil, a major feature of the Mediterranean diet, is an abundant source of phenolic compounds. Olive oil production is associated with the generation of waste material, termed ‘olive mill wastewater’ (OMWW), that has been reported to be enriched in soluble polyphenols. Given the known beneficial activity of polyphenols, we investigated whether the use of purified extracts from OMWW, termed A009, rich in hydroxytyrosol, might have anticancer activities on colon cancer (CC) cell lines in vitro and in vivo and could represent a chemopreventive preparation for CC. A009 from different batches inhibited proliferation, migration, invasion, adhesion, sprouting of CC cells and release of angiogenic, pro-inflammatory cytokines (VEGF, IL-8). Our data demonstrate that a novel purified, polyphenol enriched extract, obtained from food industry waste material, with similar activity than purified hydroxytyrosol but easier to produce in large quantities and with an environment-sensitive approach, has potential cancer chemopreventive properties for colon cancer cells.

AB - Olive oil, a major feature of the Mediterranean diet, is an abundant source of phenolic compounds. Olive oil production is associated with the generation of waste material, termed ‘olive mill wastewater’ (OMWW), that has been reported to be enriched in soluble polyphenols. Given the known beneficial activity of polyphenols, we investigated whether the use of purified extracts from OMWW, termed A009, rich in hydroxytyrosol, might have anticancer activities on colon cancer (CC) cell lines in vitro and in vivo and could represent a chemopreventive preparation for CC. A009 from different batches inhibited proliferation, migration, invasion, adhesion, sprouting of CC cells and release of angiogenic, pro-inflammatory cytokines (VEGF, IL-8). Our data demonstrate that a novel purified, polyphenol enriched extract, obtained from food industry waste material, with similar activity than purified hydroxytyrosol but easier to produce in large quantities and with an environment-sensitive approach, has potential cancer chemopreventive properties for colon cancer cells.

KW - Chemoprevention

KW - Colon cancer

KW - Hydroxytyrosol

KW - Olive mill wastewater

KW - Polyphenols

UR - http://www.scopus.com/inward/record.url?scp=84989170869&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84989170869&partnerID=8YFLogxK

U2 - 10.1016/j.jff.2016.09.009

DO - 10.1016/j.jff.2016.09.009

M3 - Article

VL - 27

SP - 236

EP - 248

JO - Journal of Functional Foods

JF - Journal of Functional Foods

SN - 1756-4646

ER -