Potential drug targets within bone morphogenetic protein signaling pathways

Elisabetta Gazzerro, Carlo Minetti

Research output: Contribution to journalArticle

Abstract

Bone morphogenetic proteins (BMPs) play an essential role in skeletal tissue, as they induce the commitment of mesenchymal cells toward cells of the osteoblastic lineage and also enhance the differentiated function of the osteoblast. BMPs are required for skeletal development, maintenance of adult bone homeostasis and fracture healing. BMP actions are tempered by extracellular and intracellular signals that block BMP signal transduction at multiple levels. Identification of these BMP regulatory molecules allows us to investigate their role in diseases that affect skeletal function and could provide a novel therapeutic intervention point for treatment. Both extracellular and intracellular antagonists are regulated by BMPs, indicating the existence and need for local feedback mechanisms to modulate BMP biological responses.

Original languageEnglish
Pages (from-to)325-333
Number of pages9
JournalCurrent Opinion in Pharmacology
Volume7
Issue number3
DOIs
Publication statusPublished - Jun 2007

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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