Potential effect of anti-inflammatory treatment on reducing the cardiovascular risk in rheumatoid arthritis

Cecilia Chighizola, Tommaso Schioppo, Francesca Ingegnoli, Pier Luigi Meroni

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory polyarthritis with increased mortality largely attributable to cardiovascular disease. There is extensive evidence that patients with RA experience accelerated atherosclerosis, which is considered as the main responsible of this increased cardiovascular burden. Nowadays atherosclerosis is regarded as an inflammatory condition: hence, the cumulative inflammation of RA, with the abundant synthesis of proinflammatory cytokines, contributes directly to the early formation of the atheromatic plaque. It is therefore reasonable to postulate that, by alleviating inflammation, drugs commonly used in RA treatment may ameliorate the cardiovascular profile of these patients. Here we provide an extensive review of the literature, focusing on the effects of the available anti-rheumatic agents on cardiovascular mortality, and morbidity among RA sufferers.

Original languageEnglish
Pages (from-to)639-646
Number of pages8
JournalCurrent Vascular Pharmacology
Volume10
Issue number5
DOIs
Publication statusPublished - 2012

Fingerprint

Rheumatoid Arthritis
Anti-Inflammatory Agents
Atherosclerosis
Inflammation
Therapeutics
Antirheumatic Agents
Mortality
Arthritis
Cardiovascular Diseases
Cytokines
Morbidity
Pharmaceutical Preparations

Keywords

  • Anti-TNF- α agents
  • Atherosclerosis
  • Cardiovascular disease
  • DMARDs
  • Inflammation
  • Novel biologic agents
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology

Cite this

Potential effect of anti-inflammatory treatment on reducing the cardiovascular risk in rheumatoid arthritis. / Chighizola, Cecilia; Schioppo, Tommaso; Ingegnoli, Francesca; Meroni, Pier Luigi.

In: Current Vascular Pharmacology, Vol. 10, No. 5, 2012, p. 639-646.

Research output: Contribution to journalArticle

Chighizola, Cecilia ; Schioppo, Tommaso ; Ingegnoli, Francesca ; Meroni, Pier Luigi. / Potential effect of anti-inflammatory treatment on reducing the cardiovascular risk in rheumatoid arthritis. In: Current Vascular Pharmacology. 2012 ; Vol. 10, No. 5. pp. 639-646.
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