Potential pitfalls in LC-MS/MS quantification of colistin for therapeutic drug monitoring of patients treated with colistimethate

Research output: Contribution to journalReview articlepeer-review

Abstract

Starting from a warning of possible artificially high plasma colistin concentrations observed in clinical samples in our recently published LC-MS/MS method, we reviewed our analytical assay and demonstrated, for the first time, that caution must be paid to ionization conditions employed in the MS system. The artefact reported here demonstrates that additional experiments should be performed in the course of validation of LC-MS/MS methods to be used in samples containing both colistin and colistimethate.

Original languageEnglish
Pages (from-to)193-195
Number of pages3
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume170
DOIs
Publication statusPublished - Jun 5 2019

Keywords

  • Chromatography, Liquid/methods
  • Colistin/analogs & derivatives
  • Drug Monitoring/methods
  • Humans
  • Tandem Mass Spectrometry/methods

Fingerprint Dive into the research topics of 'Potential pitfalls in LC-MS/MS quantification of colistin for therapeutic drug monitoring of patients treated with colistimethate'. Together they form a unique fingerprint.

Cite this