Potential protective effects of telmisartan on renal function deterioration

Andrea Remuzzi, Giuseppe Remuzzi

Research output: Contribution to journalArticlepeer-review

Abstract

Experimental and clinical evidence is now available that antagonism of angiotensin II (Ang II) with both angiotensin-converting enzyme inhibitors and Ang II receptor antagonists (AIIAs) is effective in slowing the rate of renal functional loss in patients affected by proteinuric kidney diseases. Among AIIAs, telmisartan has been shown to be characterised by a potent and long lasting antihypertensive effect that may be associated with another specific effect of this molecule, the partial agonism of the peroxisome-activated receptor-gamma. Although this action has also been observed with other AIIAs, telimisartan seems to exert a more effective and specific action as in such a way to influence beneficially adipocyte metabolism, diabetes onset and and insulin resistance. Recently, we have demonstrated, at the experimental and clinical level, that sustained blockade of Ang II biological activity with this class of compounds can potentially reduce the progression of renal dysfunction and in some circumstances induce the regression of renal functional and structural changes. In this review we analyse available experimental and clinical data that suggest that ute blocking Ang II with telmisartan may effectively ameliorate renal dysfunction in patients affected by the now frequently observed condition termed metabolic syndrome.

Original languageEnglish
Pages (from-to)185-191
Number of pages7
JournalJRAAS - Journal of the Renin-Angiotensin-Aldosterone System
Volume7
Issue number4
DOIs
Publication statusPublished - Dec 2006

Keywords

  • Angiotensen II peroxisome-activated receptor-gamma
  • Angiotensin receptor antagonist
  • Angiotensin-converting enzyme inhibitors
  • Insulin resistance renal diseases
  • Metabolic syndrome
  • Renoprotection

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology

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