Potential relationship between Helicobacter pylori and ischemic heart disease: Any pathogenic model?

M. Berrutti, R. Pellicano, S. Fagoonee, M. Astegiano, A. Smedile, G. Saracco, A. Repici, N. Leone, M. Rizzetto

Research output: Contribution to journalArticle

Abstract

Helicobacter pylori (H.pylori), causal agent of several gastroduodenal diseases, has been involved in diverse aspects of many extragastric manifestations, including ischemic heart disease (IHD). The present paper focuses on the potential pathogenic mechanisms relating H. pylori to IHD. Since H. pylori DNA has been detected in the coronary arteries only in sporadic occasions, and considering that long-term inflammation might raise cytokine levels in the bloodstream, an indirect pathway is more plausible. Moreover, the evidence that some strains of H. pylori induce platelet aggregation supports a role in the acute phase of IHD. In conclusion, because IHD is a multifactorial disease, it is evident that H. pylori is not the only cause. Thus, the definition of H. pylori or other infectious agents as culprits requires a multidisciplinary approach.

Original languageEnglish
Pages (from-to)161-163
Number of pages3
JournalPanminerva Medica
Volume50
Issue number2
Publication statusPublished - Jun 2008

Keywords

  • Helicobacter pylori
  • Myocardial infarction
  • Myocardial ischemia

ASJC Scopus subject areas

  • Medicine(all)

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    Berrutti, M., Pellicano, R., Fagoonee, S., Astegiano, M., Smedile, A., Saracco, G., Repici, A., Leone, N., & Rizzetto, M. (2008). Potential relationship between Helicobacter pylori and ischemic heart disease: Any pathogenic model? Panminerva Medica, 50(2), 161-163.