Potential role of combined FDG PET/CT & contrast enhancement MRI in a rectal carcinoma model with nodal metastases characterized by a poor FDG-avidity

Paolo Farace, Giamaica Conti, Flavia Merigo, Stefano Tambalo, Pasquina Marzola, Andrea Sbarbati, Carmelo Quarta, Daniela D'Ambrosio, Sotirios Chondrogiannis, Cristina Nanni, Domenico Rubello

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To investigate the additional role of MRI contrast enhancement (CE) in the primary tumor and the FDG uptake at PET in the lymph-node metastases. Materials and methods: A model of colorectal cancer induced by orthotopic HT-29 cells microinjection, producing pelvic lymph node metastases, was assessed using CE-MRI and FDG-PET. Histology and GLUT-1 immunohistochemistry were performed on primary tumors and iliac lymph nodes. Results: Primary tumors were characterized by low FDG-uptake but high CE-MRI, particularly at tumor periphery. Undetectable FDG-uptake characterized the metastatic lymph-nodes. Histology revealed large stromal bundles at tumor periphery and a dense network of stromal fibers and neoplastic cells in the inner portion of the tumors. Both primary tumors and positive lymph nodes showed poor GLUT-1 staining. Conclusion: Our data support the complementary role of MRI-CE and FDG PET in some types of carcinomas characterized by abundant cancer-associated stroma and poor FDG avidity consequent to poor GLUT-1 transported. In these tumors FDG-PET alone may be not completely adequate to obtain an adequate tumor radiotherapy planning, and a combination with dual CE-MRI is strongly recommended.

Original languageEnglish
Pages (from-to)658-662
Number of pages5
JournalEuropean Journal of Radiology
Volume81
Issue number4
DOIs
Publication statusPublished - Apr 2012

Keywords

  • Cancer-associated stroma
  • Carcinoma
  • Contrast enhanced MRI
  • Poor FDG uptake
  • Small animal PET

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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