Abstract
Beside their role in the control of water and electrolyte homeostasis, recent data clearly indicate that aldosterone and the mineralocorticoid receptor (MR) are involved in adipocyte biology. It has been recently shown that aldosterone promotes white and brown adipocyte differentiation in vitro through specific activation of the MR. In addition, a non-epithelial pro-inflammatory role for MR activation has been recently inferred from studies on mineralocorticoid/salt administration in experimental animal models and from clinical studies. The mineralocorticoid system could hence represent a potential target for new therapeutic strategies in obesity and the metabolic syndrome. Progesterone has high affinity for the MR and is a natural antagonist of aldosterone. Differently from classic synthetic progestins, which are devoid of antimineralocorticoid properties, progesterone and new progestogens show remarkable antimineralocorticoid effects. Here, we discuss the potential role of the antimineralocorticoid properties of progestogens in the control of body weight, adipose tissue proliferation and salt sensitivity; their therapeutic use in postmenopausal women, as well as in women affected by polycystic ovary syndrome, may open new and unexpected possibilities in the treatment of related metabolic disorders.
| Original language | English |
|---|---|
| Pages (from-to) | 258-264 |
| Number of pages | 7 |
| Journal | Climacteric |
| Volume | 11 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2008 |
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Keywords
- Adipocyte
- Hormone replacement therapy
- Mineralocorticoid receptor
- Progesterone receptor
- Progestogens
- Salt sensitivity
ASJC Scopus subject areas
- Obstetrics and Gynaecology
Cite this
Potential role of progestogens in the control of adipose tissue and salt sensitivity via interaction with the mineralocorticoid receptor. / Caprio, M.; Zennaro, M. C.; Fève, B.; Mammi, C.; Fabbri, A.; Rosano, G.
In: Climacteric, Vol. 11, No. 3, 2008, p. 258-264.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Potential role of progestogens in the control of adipose tissue and salt sensitivity via interaction with the mineralocorticoid receptor
AU - Caprio, M.
AU - Zennaro, M. C.
AU - Fève, B.
AU - Mammi, C.
AU - Fabbri, A.
AU - Rosano, G.
PY - 2008
Y1 - 2008
N2 - Beside their role in the control of water and electrolyte homeostasis, recent data clearly indicate that aldosterone and the mineralocorticoid receptor (MR) are involved in adipocyte biology. It has been recently shown that aldosterone promotes white and brown adipocyte differentiation in vitro through specific activation of the MR. In addition, a non-epithelial pro-inflammatory role for MR activation has been recently inferred from studies on mineralocorticoid/salt administration in experimental animal models and from clinical studies. The mineralocorticoid system could hence represent a potential target for new therapeutic strategies in obesity and the metabolic syndrome. Progesterone has high affinity for the MR and is a natural antagonist of aldosterone. Differently from classic synthetic progestins, which are devoid of antimineralocorticoid properties, progesterone and new progestogens show remarkable antimineralocorticoid effects. Here, we discuss the potential role of the antimineralocorticoid properties of progestogens in the control of body weight, adipose tissue proliferation and salt sensitivity; their therapeutic use in postmenopausal women, as well as in women affected by polycystic ovary syndrome, may open new and unexpected possibilities in the treatment of related metabolic disorders.
AB - Beside their role in the control of water and electrolyte homeostasis, recent data clearly indicate that aldosterone and the mineralocorticoid receptor (MR) are involved in adipocyte biology. It has been recently shown that aldosterone promotes white and brown adipocyte differentiation in vitro through specific activation of the MR. In addition, a non-epithelial pro-inflammatory role for MR activation has been recently inferred from studies on mineralocorticoid/salt administration in experimental animal models and from clinical studies. The mineralocorticoid system could hence represent a potential target for new therapeutic strategies in obesity and the metabolic syndrome. Progesterone has high affinity for the MR and is a natural antagonist of aldosterone. Differently from classic synthetic progestins, which are devoid of antimineralocorticoid properties, progesterone and new progestogens show remarkable antimineralocorticoid effects. Here, we discuss the potential role of the antimineralocorticoid properties of progestogens in the control of body weight, adipose tissue proliferation and salt sensitivity; their therapeutic use in postmenopausal women, as well as in women affected by polycystic ovary syndrome, may open new and unexpected possibilities in the treatment of related metabolic disorders.
KW - Adipocyte
KW - Hormone replacement therapy
KW - Mineralocorticoid receptor
KW - Progesterone receptor
KW - Progestogens
KW - Salt sensitivity
UR - http://www.scopus.com/inward/record.url?scp=48249111825&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=48249111825&partnerID=8YFLogxK
U2 - 10.1080/13697130802162608
DO - 10.1080/13697130802162608
M3 - Article
C2 - 18568791
AN - SCOPUS:48249111825
VL - 11
SP - 258
EP - 264
JO - Climacteric
JF - Climacteric
SN - 1369-7137
IS - 3
ER -