Potential role of the detection of enterobacterial DNA in blood for the management of neonatal necrotizing enterocolitis

Nicasio Mancini, Antonella Poloniato, Nadia Ghidoli, Silvia Carletti, Martina Fomasi, Graziano Barera, Rosanna Rovelli, Paola Cichero, Roberto Burioni, Massimo Clementi

Research output: Contribution to journalArticle

Abstract

We present three cases of pre-term low-weight infants with suspected necrotizing enterocolitis (NEC) [one eventually recognized as a connatal cytomegalovirus (CMV) infection], microbiologically monitored using a molecular assay detecting bacterial and fungal DNA in blood. The detection of DNA from enteric pathogens in blood was interpreted as a sign of ongoing perforation, and represented a useful complement in the management of the presented cases. Moreover, these cases suggest the opportunity for larger future studies to assess the possible role of a molecular approach in the close monitoring of infants with suspected NEC or with other conditions at-risk for intestinal perforation.

Original languageEnglish
Pages (from-to)1465-1472
Number of pages8
JournalJournal of Medical Microbiology
Volume61
Issue numberPART 10
DOIs
Publication statusPublished - Oct 2012

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

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