Potential statin drug interactions in elderly patients: a review

Isabella Damiani, Alberto Corsini, Stefano Bellosta

Research output: Contribution to journalReview articlepeer-review


Introduction: Persons aged more than 65 years may be more prone to suffer from chronic diseases and comorbidities (as demonstrated by the recent COVID-19 pandemics) and are treated with multiple concomitant medications. This may result in drug-drug interactions (DDIs) that are often overlooked in clinical practice. Elderly patients are more affected by comorbidities increasing the risk of DDIs and adverse drug reactions (ADRs). Statins are effective in elderly patients with or at risk for cardiovascular disease (CVD) and are prescribed on a long-term basis and may undergo DDIs, particularly on pharmacokinetic bases. The risk of DDIs varies among statins, and safety and ADRs of statins are of special concern in patients affected by multiple chronic conditions requiring concomitant therapies at risk of DDIs, such as the elderly. Areas covered: The purpose of this manuscript is to give an update on the potential statin DDIs and related ADRs with an exclusive focus on the data available in elderly patients. Expert opinion: A better and more close attention to the potential DDIs among statins and other therapeutic options will help physicians in selecting the more effective and less harmful treatment for their patients. This is of importance, especially in older patients.

Original languageEnglish
Pages (from-to)1133-1145
Number of pages13
JournalExpert Opinion on Drug Metabolism and Toxicology
Issue number12
Publication statusPublished - Dec 2020


  • Aging
  • COVID-19
  • HIV patients
  • monoclonal antibodies
  • sacubitril
  • statin pharmacokinetics
  • tocilizumab

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology


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