TY - JOUR
T1 - Potential use of modulators of oxidative stress as add-on therapy in patients with anxiety disorders
AU - Boldrini, Paolo
AU - Fusco, Antonella
AU - Nicoletti, Ferdinando
AU - Badiani, Aldo
AU - Saso, Luciano
N1 - Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
PY - 2017/4/25
Y1 - 2017/4/25
N2 - It is known that an increased oxidative stress is present in a wide range of diseases and, given the vulnerability of the central nervous system, its involvement has been in particular investigated in neurological and psychiatric diseases, including anxiety disorders. In this review we analyse the studies that have been conducted on the effects of oxidative stress modulators in anxiety, focusing on their possible clinical use. While preclinical studies have shown a clear anxiolytic-like effect of different oxidative stress modulators, less significant results have been obtained from clinical studies. After having reviewed the possible reasons for the discrepancy between preclinical and clinical data, we encourage further studies aimed at better investigating the utility of the modulation of oxidative stress in humans, as adjunctive therapy of the traditional integrated psychotherapeutic and pharmacological approach.
AB - It is known that an increased oxidative stress is present in a wide range of diseases and, given the vulnerability of the central nervous system, its involvement has been in particular investigated in neurological and psychiatric diseases, including anxiety disorders. In this review we analyse the studies that have been conducted on the effects of oxidative stress modulators in anxiety, focusing on their possible clinical use. While preclinical studies have shown a clear anxiolytic-like effect of different oxidative stress modulators, less significant results have been obtained from clinical studies. After having reviewed the possible reasons for the discrepancy between preclinical and clinical data, we encourage further studies aimed at better investigating the utility of the modulation of oxidative stress in humans, as adjunctive therapy of the traditional integrated psychotherapeutic and pharmacological approach.
KW - Journal Article
U2 - 10.2174/1389450118666170425153356
DO - 10.2174/1389450118666170425153356
M3 - Article
C2 - 28443504
JO - Current Drug Targets
JF - Current Drug Targets
SN - 1389-4501
ER -