Potentially inappropriate prescribing of oral solid medications in elderly dysphagic patients

Matteo Sestili, Serena Logrippo, Marco Cespi, Giulia Bonacucina, Letizia Ferrara, Silvia Busco, Iolanda Grappasonni, Giovanni Filippo Palmieri, Roberta Ganzetti, Paolo Blasi

Research output: Contribution to journalArticle

Abstract

Pharmaceutical formulations suitable for dysphagic patients are not always commercially available, motivating caregivers to crush tablets or open capsules to facilitate swallowing. Since this action may modify the characteristics of the medicine, it should be considered potentially inappropriate. This paper is the first to focus on how hospitalization affected the rate of potentially inappropriate prescriptions (PIPs) and the incidence of dosage form-related PIPs in elderly patients with dysphagia. Data was collected by reviewing patient medical records in the Italian National Research Center on Aging of Ancona. The therapy at admission and discharge was analysed in terms of: inappropriate drug associations, inappropriate drugs for dysphagic patients, inappropriate dosage forms and inappropriate dosage form modifications. Forty-one dysphagic patients with an average age of 88.3 years were included in the study and 451 prescriptions were analysed. PIPs were widespread at admission, and hospitalization did not improve the situation in a statistically significant manner. The most common PIPs identified (>80%) were related to dosage form selection and modification. This study highlights a clear need for continuing medical education about prescription appropriateness and modification of solid dosage forms in patients with dysphagia.

Original languageEnglish
Article number280
JournalPharmaceutics
Volume10
Issue number4
DOIs
Publication statusPublished - Jan 1 2018

Keywords

  • Capsules
  • Compounding
  • Inappropriate prescriptions
  • Manipulation
  • Old-old patients
  • Solid oral dosage form
  • Tablets

ASJC Scopus subject areas

  • Pharmaceutical Science

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  • Cite this

    Sestili, M., Logrippo, S., Cespi, M., Bonacucina, G., Ferrara, L., Busco, S., Grappasonni, I., Palmieri, G. F., Ganzetti, R., & Blasi, P. (2018). Potentially inappropriate prescribing of oral solid medications in elderly dysphagic patients. Pharmaceutics, 10(4), [280]. https://doi.org/10.3390/pharmaceutics10040280