Potentiation of interferon-γ-stimulated nitric oxide production by retinoic acid in RAW 264.7 cells

L. M I Austenaa; A. Catharine Ross

Potentiation of interferon-γ-stimulated nitric oxide production by retinoic acid in RAW 264.7 cells

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

Nitric oxide (NO) production is essential for normal immunity. We have examined the capacity of retinoic acid (RA), a pleiotropic hormone necessary for normal immunity, to modulate NO production in RAW 264.7 cells. NO production induced by suboptimal concentrations of interferon-γ (IFN-γ) was significantly greater in cells cultured in low-retinoid medium and treated with all-trans-RA (10^-10 - 10^-6 M, P

Original language	English
Pages (from-to)	121-129
Number of pages	9
Journal	Journal of Leukocyte Biology
Volume	70
Issue number	1
Publication status	Published - 2001

Keywords

Immune regulation
Lipopolysaccharide
Monophosphoryl lipid A
T-helper-cell differentiation

ASJC Scopus subject areas

Cell Biology

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Potentiation of interferon-γ-stimulated nitric oxide production by retinoic acid in RAW 264.7 cells

Abstract

Keywords

ASJC Scopus subject areas

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