Potentiation of interferon-γ-stimulated nitric oxide production by retinoic acid in RAW 264.7 cells

L. M I Austenaa, A. Catharine Ross

Research output: Contribution to journalArticlepeer-review

Abstract

Nitric oxide (NO) production is essential for normal immunity. We have examined the capacity of retinoic acid (RA), a pleiotropic hormone necessary for normal immunity, to modulate NO production in RAW 264.7 cells. NO production induced by suboptimal concentrations of interferon-γ (IFN-γ) was significantly greater in cells cultured in low-retinoid medium and treated with all-trans-RA (10-10 - 10-6 M, P

Original languageEnglish
Pages (from-to)121-129
Number of pages9
JournalJournal of Leukocyte Biology
Volume70
Issue number1
Publication statusPublished - 2001

Keywords

  • Immune regulation
  • Lipopolysaccharide
  • Monophosphoryl lipid A
  • T-helper-cell differentiation

ASJC Scopus subject areas

  • Cell Biology

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