Potentiation of ischemia-related behavioral alterations by electro-acupuncture in gerbils

Leonardo Restivo, Silvia Middei, Luo Mingfu, Rosaria Reggio, Enrica Passino, Rita Formisano, Martine Ammassari-Teule

Research output: Contribution to journalArticle


Gerbils subjected to global ischemia or sham-ischemia received electro-acupuncture (EA) or sham EA at points 26 Du (Renzhong) and 8 Du (Junsuo). All animals were then tested for motor activity in an open field, and for spontaneous alternation in a T maze. Results show that EA alone did not affect any behavioral parameter. Ischemia alone increased motor activity without significantly interfering with spontaneous alternation. EA in ischemic gerbils potentiated the increase of motor activity and elicited a decrease in spontaneous alternation. Thus, our data show an interaction between global ischemia and EA applied at specific acupoints which, however, consists of a potentiation rather than an alleviation of the behavioral alterations consecutive to the ischemic insult.

Original languageEnglish
Pages (from-to)19-23
Number of pages5
JournalFunctional Neurology
Issue number1
Publication statusPublished - Jan 2004



  • Electro-acupuncture
  • Functional recovery
  • Global ischemia
  • Motor activity
  • Spontaneous alternation

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Restivo, L., Middei, S., Mingfu, L., Reggio, R., Passino, E., Formisano, R., & Ammassari-Teule, M. (2004). Potentiation of ischemia-related behavioral alterations by electro-acupuncture in gerbils. Functional Neurology, 19(1), 19-23.