Power spectrum analysis contribution to the detection of cardiovascular dysautonomia in multiple sclerosis

M. Frontoni, M. Fiorini, S. Strano, S. Cerutti, F. Giubilei, C. Urani, S. Bastianello, C. Pozzilli

Research output: Contribution to journalArticle

Abstract

In multiple sclerosis (MS) autonomic cardiovascular dysfunction is an uncommon, but potentially dangerous event, to which studies of spectral analysis of heart rate variability have not been applied, yet. Material and methods. We studied 16 patients with definite MS (11 women and 5 men, mean age 30.3 ± 7.4 yrs., mean EDSS 2.06 ± 1.42) and 16 sex- and age-matched healthy controls. Besides cardiovascular reflex tests (valsalva manoeuvre, deep breathing, lying to standing, Blood Pressure response to standing and sustained handgrip), each underwent spectral analysis of the R-R interval short-term variability at rest and after tilting, to detect three components: very low frequency (VLF), low frequency (LF) and high frequency (HF). A recent brain MRI was obtained from patients, to compare plaque characteristics with spectral parameters. Results. At cardiovascular reflexes, only four patients (25%) showed an impairment, mostly of a mild degree. VLF and LF at rest were lower in MS subjects than in controls (p

Original languageEnglish
Pages (from-to)241-245
Number of pages5
JournalActa Neurologica Scandinavica
Volume93
Issue number4
Publication statusPublished - 1996

Keywords

  • Autonomic nervous system
  • Cardiovascular reflexes
  • Heart rate variability
  • Magnetic resonance imaging
  • Multiple sclerosis
  • Power spectrum analysis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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    Frontoni, M., Fiorini, M., Strano, S., Cerutti, S., Giubilei, F., Urani, C., Bastianello, S., & Pozzilli, C. (1996). Power spectrum analysis contribution to the detection of cardiovascular dysautonomia in multiple sclerosis. Acta Neurologica Scandinavica, 93(4), 241-245.