pp-120: A common endogenous substrate for insulin and IGF-1 receptor-associated tyrosine kinase activity in the highly malignant AS-30D rat hepatoma cells

Maurizio Fanciulli, Marco G. Paggi, Andrea Mancini, Carlo Del Carlo, Aristide Floridi, Simeon I. Taylor, Nicola Perrotti

Research output: Contribution to journalArticlepeer-review

Abstract

Receptors for Insulin, Epidermal Growth Factor, Platelet-Derived Growth Factor and Insulin-like Growth Factor type 1 are tyrosine-specific protein kinases. This enzymatic activity may play a role in mediating the biological actions of these peptides. It has recently been identified a Mr 120 KDa glycoprotein in rat liver plasma membranes which can be phosphorylated by the insulin receptor and by the EGF receptor in a cell-free system and by the insulin receptor in intact cultured H-35 hepatoma cells. In the present report it is shown that the solubilized Insulin-like Growth Factor type 1 receptor can phosphorylate tyrosine residues in the same 120 KDa glycoprotein from the AS-30D rat hepatoma cells.

Original languageEnglish
Pages (from-to)168-173
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume160
Issue number1
DOIs
Publication statusPublished - Apr 14 1989

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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