PPAR-contributes to the anti-inflammatory activity of verbascoside in a model of inflammatory bowel disease in mice

Salvatore Cuzzocrea, Emanuela Esposito, Emanuela Mazzon, Irene Paterniti, Roberto Dal Toso, Giovanna Pressi, Rocco Caminiti

Research output: Contribution to journalArticlepeer-review

Abstract

The previous results suggest that peroxisome proliferator-activated receptor-alpha (PPAR)-, an intracellular transcription factor activated by fatty acids, plays a role in control of inflammation. There is persuasive epidemiological and experimental evidence that dietary polyphenols have anti-inflammatory activity. In this regard, it has been demonstrated that verbascoside (VB) functions as intracellular radical scavenger and reduces the microscopic and macroscopic signs of experimental colitis. With the aim to characterize the role of PPAR-in VB-mediated anti-inflammatory activity, we tested the efficacy of VB in an experimental model of inflammatory bowel disease induced by dinitrobenzene sulfonic acid, comparing mice lacking PPAR-(PPAR-KO) with wild type (WT) mice. Results indicate that VB-mediated anti-inflammatory activity is weakened in PPAR-KO mice, compared to WT controls, especially in the inhibition of neutrophil infiltration, intestinal permeability and colon injury. These results indicate that PPAR-can contribute to the anti-inflammatory activity of VB in inflammatory bowel disease.

Original languageEnglish
Article number917312
JournalPPAR Research
DOIs
Publication statusPublished - 2010

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Drug Discovery

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