PPARs signaling and cancer in the gastrointestinal system

Valerio Pazienza; Manlio Vinciguerra; Gianluigi Mazzoccoli

doi:10.1155/2012/560846

PPARs signaling and cancer in the gastrointestinal system

Valerio Pazienza, Manlio Vinciguerra, Gianluigi Mazzoccoli

IRCCS Casa Sollievo della Sofferenza

Research output: Contribution to journal › Article › peer-review

Abstract

Nowadays, the study of the peroxisome proliferators activated receptors (PPARs) as potential targets for cancer prevention and therapy has gained a strong interest. From a biological point of view, the overall responsibility of PPARs in cancer development and progression is still controversial since several studies report both antiproliferative and tumor-promoting actions for these signaling molecules in human cancer cells and animal models. In this paper, we discuss PPARs functions in the context of different types of gastrointestinal cancer.

Original language	English
Article number	560846
Journal	PPAR Research
DOIs	https://doi.org/10.1155/2012/560846
Publication status	Published - 2012

ASJC Scopus subject areas

Pharmacology (medical)
Drug Discovery

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