PPARs signaling and cancer in the gastrointestinal system

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Nowadays, the study of the peroxisome proliferators activated receptors (PPARs) as potential targets for cancer prevention and therapy has gained a strong interest. From a biological point of view, the overall responsibility of PPARs in cancer development and progression is still controversial since several studies report both antiproliferative and tumor-promoting actions for these signaling molecules in human cancer cells and animal models. In this paper, we discuss PPARs functions in the context of different types of gastrointestinal cancer.

Original languageEnglish
Article number560846
JournalPPAR Research
Publication statusPublished - 2012

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Drug Discovery


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