Abstract
Nowadays, the study of the peroxisome proliferators activated receptors (PPARs) as potential targets for cancer prevention and therapy has gained a strong interest. From a biological point of view, the overall responsibility of PPARs in cancer development and progression is still controversial since several studies report both antiproliferative and tumor-promoting actions for these signaling molecules in human cancer cells and animal models. In this paper, we discuss PPARs functions in the context of different types of gastrointestinal cancer.
| Original language | English |
|---|---|
| Article number | 560846 |
| Journal | PPAR Research |
| DOIs | |
| Publication status | Published - 2012 |
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ASJC Scopus subject areas
- Pharmacology (medical)
- Drug Discovery
Cite this
PPARs signaling and cancer in the gastrointestinal system. / Pazienza, Valerio; Vinciguerra, Manlio; Mazzoccoli, Gianluigi.
In: PPAR Research, 2012.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - PPARs signaling and cancer in the gastrointestinal system
AU - Pazienza, Valerio
AU - Vinciguerra, Manlio
AU - Mazzoccoli, Gianluigi
PY - 2012
Y1 - 2012
N2 - Nowadays, the study of the peroxisome proliferators activated receptors (PPARs) as potential targets for cancer prevention and therapy has gained a strong interest. From a biological point of view, the overall responsibility of PPARs in cancer development and progression is still controversial since several studies report both antiproliferative and tumor-promoting actions for these signaling molecules in human cancer cells and animal models. In this paper, we discuss PPARs functions in the context of different types of gastrointestinal cancer.
AB - Nowadays, the study of the peroxisome proliferators activated receptors (PPARs) as potential targets for cancer prevention and therapy has gained a strong interest. From a biological point of view, the overall responsibility of PPARs in cancer development and progression is still controversial since several studies report both antiproliferative and tumor-promoting actions for these signaling molecules in human cancer cells and animal models. In this paper, we discuss PPARs functions in the context of different types of gastrointestinal cancer.
UR - http://www.scopus.com/inward/record.url?scp=84867344609&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84867344609&partnerID=8YFLogxK
U2 - 10.1155/2012/560846
DO - 10.1155/2012/560846
M3 - Article
C2 - 23028383
AN - SCOPUS:84867344609
JO - PPAR Research
JF - PPAR Research
SN - 1687-4757
M1 - 560846
ER -