combining FN secretion and recycling of active a5b1 integrin from the trans-Golgi network (TGN) to the EC surface, thus allowing FN fibrillogenesis. In this framework, PPFIA1 interacts with active a5b1 integrin and localizes close to EC adhesions where post-Golgi carriers are targeted. We show that PPFIA1 is required for FN polymerization-dependent vascular morphogenesis,
both in vitro and in the developing zebrafish embryo.
|Publication status||Published - 2016|