PR Interval and Junctional Zone

Giuseppe Bagliani, Domenico Giovanni Della Rocca, Luigi Di Biase, Luigi Padeletti

Research output: Contribution to journalReview article


The atrioventricular junction is a pivotal component of the cardiac conduction system, a key electrical relay site between the atria and the ventricles. The sophisticated functions carried out by the atrioventricular junction are possible for the presence of a complex apparatus made of specialized anatomic structures, cells with specific ion-channel expression, a well-organized spatial distribution of intercellular junctions (connexins), cells with intrinsic automatism, and a rich autonomic innervation. This article reviews the main anatomic and electrophysiologic features of the atrioventricular junction, with a focus on cardiac preexcitation.

Original languageEnglish
Pages (from-to)411-433
Number of pages23
JournalCardiac Electrophysiology Clinics
Issue number3
Publication statusPublished - Sep 1 2017



  • Accessory pathway
  • Atrioventricular junction
  • Cardiac pre-excitation
  • PR interval
  • Wenckebach periodicity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Bagliani, G., Della Rocca, D. G., Di Biase, L., & Padeletti, L. (2017). PR Interval and Junctional Zone. Cardiac Electrophysiology Clinics, 9(3), 411-433.