TY - JOUR
T1 - Practical considerations for cangrelor use in patients with acute coronary syndromes
AU - Leonardi, Sergio
AU - Bhatt, Deepak L.
PY - 2019/2/1
Y1 - 2019/2/1
N2 - Cangrelor, the first and currently only available intravenous P2Y12 receptor antagonist, has been approved and is now being used in patients with coronary artery disease requiring percutaneous coronary intervention. The rationale for cangrelor use is most robust in patients requiring an immediate, profound, and predictable level of P2Y12 inhibition - especially in patients with acute coronary syndromes. Herein we summarize the drug development program and reflect on practical considerations for clinicians on cangrelor use in the acute setting surrounding percutaneous coronary intervention, including selection of patients, concomitant administration of glycoprotein IIb/IIIa inhibitors and transition strategies from intravenous to oral P2Y12 receptor antagonists.
AB - Cangrelor, the first and currently only available intravenous P2Y12 receptor antagonist, has been approved and is now being used in patients with coronary artery disease requiring percutaneous coronary intervention. The rationale for cangrelor use is most robust in patients requiring an immediate, profound, and predictable level of P2Y12 inhibition - especially in patients with acute coronary syndromes. Herein we summarize the drug development program and reflect on practical considerations for clinicians on cangrelor use in the acute setting surrounding percutaneous coronary intervention, including selection of patients, concomitant administration of glycoprotein IIb/IIIa inhibitors and transition strategies from intravenous to oral P2Y12 receptor antagonists.
KW - Acute coronary syndromes
KW - cangrelor
KW - percutaneous coronary intervention
UR - http://www.scopus.com/inward/record.url?scp=85061286862&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85061286862&partnerID=8YFLogxK
U2 - 10.1177/2048872617707960
DO - 10.1177/2048872617707960
M3 - Article
C2 - 28574274
AN - SCOPUS:85061286862
VL - 8
SP - 39
EP - 44
JO - European Heart Journal: Acute Cardiovascular Care
JF - European Heart Journal: Acute Cardiovascular Care
SN - 2048-8726
IS - 1
ER -