Practical considerations for cangrelor use in patients with acute coronary syndromes

Sergio Leonardi; Deepak L. Bhatt

doi:10.1177/2048872617707960

Practical considerations for cangrelor use in patients with acute coronary syndromes

Sergio Leonardi, Deepak L. Bhatt

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

Cangrelor, the first and currently only available intravenous P2Y12 receptor antagonist, has been approved and is now being used in patients with coronary artery disease requiring percutaneous coronary intervention. The rationale for cangrelor use is most robust in patients requiring an immediate, profound, and predictable level of P2Y12 inhibition - especially in patients with acute coronary syndromes. Herein we summarize the drug development program and reflect on practical considerations for clinicians on cangrelor use in the acute setting surrounding percutaneous coronary intervention, including selection of patients, concomitant administration of glycoprotein IIb/IIIa inhibitors and transition strategies from intravenous to oral P2Y12 receptor antagonists.

Original language	English
Pages (from-to)	39-44
Number of pages	6
Journal	European heart journal. Acute cardiovascular care
Volume	8
Issue number	1
DOIs	https://doi.org/10.1177/2048872617707960
Publication status	Published - Feb 1 2019

Keywords

Acute coronary syndromes
cangrelor
percutaneous coronary intervention

ASJC Scopus subject areas

Medicine(all)

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10.1177/2048872617707960

Cite this

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AB - Cangrelor, the first and currently only available intravenous P2Y12 receptor antagonist, has been approved and is now being used in patients with coronary artery disease requiring percutaneous coronary intervention. The rationale for cangrelor use is most robust in patients requiring an immediate, profound, and predictable level of P2Y12 inhibition - especially in patients with acute coronary syndromes. Herein we summarize the drug development program and reflect on practical considerations for clinicians on cangrelor use in the acute setting surrounding percutaneous coronary intervention, including selection of patients, concomitant administration of glycoprotein IIb/IIIa inhibitors and transition strategies from intravenous to oral P2Y12 receptor antagonists.

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Practical considerations for cangrelor use in patients with acute coronary syndromes

Abstract

Keywords

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