Practical considerations in the use of regorafenib in metastatic colorectal cancer. Therapeutic advances in medical oncology

Fotios Loupakis, Lorenzo Antonuzzo, Jean-Baptiste Bachet, Feng-Che Kuan, Teresa Macarulla, Filippo Pietrantonio, Rui-Hua Xu, Hiroya Taniguchi, Thomas Winder, Satoshi Yuki, Shan Zeng, Tanios Bekaii-Saab

Research output: Contribution to journalArticlepeer-review

Abstract

Over the past 20 years, management of patients with metastatic colorectal cancer (mCRC) has improved considerably, leading to increased overall survival and more patients eligible for third- or later-line therapy. Currently, two oral therapies are recommended in the third-line treatment of mCRC, regorafenib and trifluridine/tipiracil. Selecting the most appropriate treatment in the third-line setting poses different challenges compared with treatment selection at earlier stages. Therefore, it is important for physicians to understand and differentiate between available treatment options and to communicate the benefits and challenges of these to patients. In this narrative review, practical information on regorafenib is provided to aid physicians in their decision-making and patient communications in daily practice. We discuss the importance of appropriate patient selection and adverse events management through close patient monitoring and dose adjustments to ensure patients stay on treatment for longer and receive as much benefit as possible. We also highlight key physician-patient communication points to facilitate shared decision-making.
Original languageEnglish
Pages (from-to)1758835920956862
JournalTher. Adv. Med. Oncol.
Volume12
DOIs
Publication statusPublished - 2020

Keywords

  • adverse events
  • metastatic colorectal cancer
  • practical management
  • regorafenib
  • third line

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