TY - JOUR
T1 - Practical tools to identify short children born small-for-gestational-age eligible for rhGH treatment according to Italian regulation
AU - Tornese, Gianluca
AU - Pricci, Flavia
AU - Pellegrin, Maria Chiara
AU - Villa, Marika
AU - Rotondi, Daniela
AU - Agazio, Elvira
AU - Barbi, Egidio
PY - 2019/10/21
Y1 - 2019/10/21
N2 - Recombinant human growth hormone (rhGH) is an approved and effective treatment for short children born small for gestational age (SGA). Prevalence of children eligible for treatment as SGA is reported to be 1:1800. The latest data from the National Registry of Growth Hormone therapy (RNAOC) showed that the number of children treated with SGA indication is still small (prevalence 0.37/100,000) and these children are significantly less reported than those treated for growth hormone deficiency (GHD), although GHD prevalence is 1:4000-1:10,000. This means that many short children born SGA are still not properly identified, and therefore not treated with rhGH, or misdiagnosed as GHD. This article provides some practical tools for the identification of children eligible for rhGH treatment.
AB - Recombinant human growth hormone (rhGH) is an approved and effective treatment for short children born small for gestational age (SGA). Prevalence of children eligible for treatment as SGA is reported to be 1:1800. The latest data from the National Registry of Growth Hormone therapy (RNAOC) showed that the number of children treated with SGA indication is still small (prevalence 0.37/100,000) and these children are significantly less reported than those treated for growth hormone deficiency (GHD), although GHD prevalence is 1:4000-1:10,000. This means that many short children born SGA are still not properly identified, and therefore not treated with rhGH, or misdiagnosed as GHD. This article provides some practical tools for the identification of children eligible for rhGH treatment.
KW - Growth hormone
KW - Italy
KW - Small for gestational age
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U2 - 10.1186/s13052-019-0715-x
DO - 10.1186/s13052-019-0715-x
M3 - Review article
C2 - 31639023
AN - SCOPUS:85073735115
VL - 45
JO - Italian Journal of Pediatrics
JF - Italian Journal of Pediatrics
SN - 1720-8424
IS - 1
M1 - 130
ER -