TY - JOUR
T1 - PRactice of VENTilation in Middle-Income Countries (PRoVENT-iMIC)
T2 - Rationale and protocol for a prospective international multicentre observational study in intensive care units in Asia
AU - Pisani, Luigi
AU - Algera, Anna Geke
AU - Serpa Neto, Ary
AU - Ahsan, Areef
AU - Beane, Abigail
AU - Chittawatanarat, Kaweesak
AU - Faiz, Abul
AU - Haniffa, Rashan
AU - Hashemian, Reza
AU - Hashmi, Madiha
AU - Imad, Hisham Ahmed
AU - Indraratna, Kanishka
AU - Iyer, Shivakumar
AU - Kayastha, Gyan
AU - Krishna, Bhuvana
AU - Moosa, Hassan
AU - Nadjm, Behzad
AU - Pattnaik, Rajyabardhan
AU - Sampath, Sriram
AU - Thwaites, Louise
AU - Tun, Ni Ni
AU - Yunos, Nor'Azim Mohd
AU - Grasso, Salvatore
AU - Paulus, Frederique
AU - De Abreu, Marcelo Gama
AU - Pelosi, Paolo
AU - Dondorp, Arjen M.
AU - Schultz, Marcus J.
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Introduction Current evidence on epidemiology and outcomes of invasively mechanically ventilated intensive care unit (ICU) patients is predominantly gathered in resource-rich settings. Patient casemix and patterns of critical illnesses, and probably also ventilation practices are likely to be different in resource-limited settings. We aim to investigate the epidemiological characteristics, ventilation practices and clinical outcomes of patients receiving mechanical ventilation in ICUs in Asia. Methods and analysis PRoVENT-iMIC (study of PRactice of VENTilation in Middle-Income Countries) is an international multicentre observational study to be undertaken in approximately 60 ICUs in 11 Asian countries. Consecutive patients aged 18 years or older who are receiving invasive ventilation in participating ICUs during a predefined 28-day period are to be enrolled, with a daily follow-up of 7 days. The primary outcome is ventilatory management (including tidal volume expressed as mL/kg predicted body weight and positive end-expiratory pressure expressed as cm H 2 O) during the first 3 days of mechanical ventilation - compared between patients at no risk for acute respiratory distress syndrome (ARDS), patients at risk for ARDS and in patients with ARDS (in case the diagnosis of ARDS can be made on admission). Secondary outcomes include occurrence of pulmonary complications and all-cause ICU mortality. Ethics and dissemination PRoVENT-iMIC will be the first international study that prospectively assesses ventilation practices, outcomes and epidemiology of invasively ventilated patients in ICUs in Asia. The results of this large study, to be disseminated through conference presentations and publications in international peer-reviewed journals, are of ultimate importance when designing trials of invasive ventilation in resource-limited ICUs. Access to source data will be made available through national or international anonymised datasets on request and after agreement of the PRoVENT-iMIC steering committee. Trial registration number NCT03188770; Pre-results.
AB - Introduction Current evidence on epidemiology and outcomes of invasively mechanically ventilated intensive care unit (ICU) patients is predominantly gathered in resource-rich settings. Patient casemix and patterns of critical illnesses, and probably also ventilation practices are likely to be different in resource-limited settings. We aim to investigate the epidemiological characteristics, ventilation practices and clinical outcomes of patients receiving mechanical ventilation in ICUs in Asia. Methods and analysis PRoVENT-iMIC (study of PRactice of VENTilation in Middle-Income Countries) is an international multicentre observational study to be undertaken in approximately 60 ICUs in 11 Asian countries. Consecutive patients aged 18 years or older who are receiving invasive ventilation in participating ICUs during a predefined 28-day period are to be enrolled, with a daily follow-up of 7 days. The primary outcome is ventilatory management (including tidal volume expressed as mL/kg predicted body weight and positive end-expiratory pressure expressed as cm H 2 O) during the first 3 days of mechanical ventilation - compared between patients at no risk for acute respiratory distress syndrome (ARDS), patients at risk for ARDS and in patients with ARDS (in case the diagnosis of ARDS can be made on admission). Secondary outcomes include occurrence of pulmonary complications and all-cause ICU mortality. Ethics and dissemination PRoVENT-iMIC will be the first international study that prospectively assesses ventilation practices, outcomes and epidemiology of invasively ventilated patients in ICUs in Asia. The results of this large study, to be disseminated through conference presentations and publications in international peer-reviewed journals, are of ultimate importance when designing trials of invasive ventilation in resource-limited ICUs. Access to source data will be made available through national or international anonymised datasets on request and after agreement of the PRoVENT-iMIC steering committee. Trial registration number NCT03188770; Pre-results.
KW - Ards
KW - Invasive Ventilation
KW - Mechanical Ventilation
KW - Middle-income Countries
KW - Outcomes
KW - Resource-limited Settings
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U2 - 10.1136/bmjopen-2017-020841
DO - 10.1136/bmjopen-2017-020841
M3 - Article
C2 - 29705765
AN - SCOPUS:85057037600
VL - 8
JO - BMJ Open
JF - BMJ Open
SN - 2044-6055
IS - 4
M1 - e020841
ER -