Pramipexole in comparison to 1-dopa

A neuropsychological study

L. Brusa, A. Bassi, A. Stefani, M. Pierantozzi, A. Peppe, M. D. Caramia, L. Boffa, S. Ruggieri, P. Stanzione

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Twenty right-handed patients affected by early/mild Parkinson's disease were evaluated in a randomised study using neuropsychological and clinical assessements during three treatment modalities: when in the off treatment condition, when on pramipexole, and when on 1-dopa. In comparison to the off treatment condition, the DA-agonist pramipexole produced a significant impairment of short term verbal memory, attentional-executive functions and verbal fluency, while 1-dopa did not. Moreover, pramipexole opposite to 1-dopa, failed to improve FAS and Stroop tests. Present findings indicate that pramipexole may worsen cognitive functions although not exceeding normative values.

Original languageEnglish
Pages (from-to)373-380
Number of pages8
JournalJournal of Neural Transmission
Volume110
Issue number4
DOIs
Publication statusPublished - Apr 1 2003

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Dihydroxyphenylalanine
Stroop Test
Executive Function
Patient Rights
Short-Term Memory
Cognition
Parkinson Disease
pramipexole

Keywords

  • 1-Dopa
  • Cognitive function
  • DA-agonists

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Brusa, L., Bassi, A., Stefani, A., Pierantozzi, M., Peppe, A., Caramia, M. D., ... Stanzione, P. (2003). Pramipexole in comparison to 1-dopa: A neuropsychological study. Journal of Neural Transmission, 110(4), 373-380. https://doi.org/10.1007/s00702-002-0811-7

Pramipexole in comparison to 1-dopa : A neuropsychological study. / Brusa, L.; Bassi, A.; Stefani, A.; Pierantozzi, M.; Peppe, A.; Caramia, M. D.; Boffa, L.; Ruggieri, S.; Stanzione, P.

In: Journal of Neural Transmission, Vol. 110, No. 4, 01.04.2003, p. 373-380.

Research output: Contribution to journalArticle

Brusa, L, Bassi, A, Stefani, A, Pierantozzi, M, Peppe, A, Caramia, MD, Boffa, L, Ruggieri, S & Stanzione, P 2003, 'Pramipexole in comparison to 1-dopa: A neuropsychological study', Journal of Neural Transmission, vol. 110, no. 4, pp. 373-380. https://doi.org/10.1007/s00702-002-0811-7
Brusa, L. ; Bassi, A. ; Stefani, A. ; Pierantozzi, M. ; Peppe, A. ; Caramia, M. D. ; Boffa, L. ; Ruggieri, S. ; Stanzione, P. / Pramipexole in comparison to 1-dopa : A neuropsychological study. In: Journal of Neural Transmission. 2003 ; Vol. 110, No. 4. pp. 373-380.
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