Pramiracetam: A nootropic agent with improved efficacy in patients with senile or presenile cognitive impairment

G. Nappi, X. Rabasseda, N. Mealy

Research output: Contribution to journalArticle


As the mean age of the general population increases, so does the need for reliable drugs for improving cognitive-memory disturbances in the elderly. Nootropic agents have been shown to improve memory and learning processes in animals and to be useful in patients with several types of senile or traumatic dementia. Pramiracetam, one of the newest nootropics to be launched, has exhibited good efficacy in both animal models of memory or learning impairment and patients with senile and presenile cognitive impairment, including dementia of the Alzheimer type. The exact mechanism of action of this drug has not been fully established, but clinical data on good efficacy, favorable pharmacokinetic properties and advantageous safety even on prolonged treatment make it a reasonable choice for treating attention and memory alterations in elderly patients with degenerative or vascular brain diseases.

Original languageEnglish
Pages (from-to)469-482
Number of pages14
JournalDrugs of Today
Issue number6
Publication statusPublished - 1994


ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology (medical)
  • Pharmacology

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