Pramiracetam effects on scopolamine-induced amnesia in healthy volunteers

Marco Mauri, Elena Sinforiani, Fabio Reverberi, Paola Merlo, Giorgio Bono

Research output: Contribution to journalArticle

Abstract

Pramiracetam has been evaluated for its potential antiamnesic properties in scopolamine-induced amnesia in healthy volunteers. Two groups of twelve males, 18-42 and 55-65 years old, respectively, were randomly assigned to oral treatment with pramiracetam (600 mg twice a day) or with placebo for 10 consecutive days. On day 11 each subject was injected intramascularly with scopolamine hydrobromide (0.5 mg). Before scopolamine injection and then 1, 3 and 6 h after it, subjects were administered the following psychometric tests: simple and choice visual reaction times, digit symbol substitution test, Rey's 15 words test for short and long term verbal memory. Scopolamine significantly impaired episodic memory and selective attention tests in both scopolamine and placebo groups. Instead visuo-motor and incidental learning measures were unaffected. Pramiracetam, when compared to placebo, was able to partially reduce the amnesic effects induced by scopolamine both in young and old subjects.

Original languageEnglish
Pages (from-to)133-139
Number of pages7
JournalArchives of Gerontology and Geriatrics
Volume18
Issue number2
DOIs
Publication statusPublished - 1994

Keywords

  • Memory
  • Pramiracetam
  • Scopolamine

ASJC Scopus subject areas

  • Ageing
  • Medicine(all)

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