Pramlintide reduced markers of oxidative stress in the postprandial period in patients with type 2 diabetes

Antonio Ceriello, Cameron W. Lush, Tamara Darsow, Ludovica Piconi, Maddelena Corgnali, Nuwan Nanayakkara, Juan P. Frias, David Maggs

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The production of oxidative stress as a result of postprandial hyperglycaemia is now recognized as an important contributing factor in the development of diabetes complications. The objective of this study was to examine the effects of pramlintide on plasma concentrations of glucose and several markers of oxidative stress in patients with type 2 diabetes following a standardized meal. Methods: This was a randomized, single-blind, placebo-controlled, crossover study conducted at two clinical research centres in the United States. A total of 19 subjects (9 men and 10 women) with type 2 diabetes using mealtime insulin participated in the study. Pramlintide (120 μg), or placebo, and rapid-acting mealtime insulin were administered prior to a standardized meal on two separate study days. Plasma concentrations of glucose, nitrotyrosine (NT), oxidized-LDL cholesterol (OxLDL-C), and total radical trapping parameter (TRAP) were assessed during the 4-h postprandial period. Results: Compared to placebo, pramlintide treatment reduced postprandial excursions of glucose, NT, and OxLDL-C and protected TRAP from consumption. Correlation analysis revealed positive associations between placebo-corrected glucose incremental AUCO-4h and both NT and OxLDL-C and a negative association between placebo-corrected glucose incremental AUC0-4h and TRAP. Conclusions: The reduction in postprandial glucose excursions achieved with addition of pramlintide to rapid-acting insulin in type 2 diabetes was associated with a reduction in postprandial markers of oxidative stress.

Original languageEnglish
Pages (from-to)103-108
Number of pages6
JournalDiabetes/Metabolism Research and Reviews
Volume24
Issue number2
DOIs
Publication statusPublished - Feb 2008

Keywords

  • Markers of oxidative stress
  • Pramlintide
  • Type 2 diabetes

ASJC Scopus subject areas

  • Endocrinology
  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

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