TY - JOUR
T1 - Prasugrel versus clopidogrel in patients with acute coronary syndromes
AU - Wiviott, Stephen D.
AU - Braunwald, Eugene
AU - McCabe, Carolyn H.
AU - Montalescot, Gilles
AU - Ruzyllo, Witold
AU - Gottlieb, Shmuel
AU - Neumann, Franz Joseph
AU - Ardissino, Diego
AU - De Servi, Stefano
AU - Murphy, Sabina A.
AU - Riesmeyer, Jeffrey
AU - Weerakkody, Govinda
AU - Gibson, C. Michael
AU - Antman, Elliott M.
PY - 2007/11/15
Y1 - 2007/11/15
N2 - BACKGROUND: Dual-antiplatelet therapy with aspirin and a thienopyridine is a cornerstone of treatment to prevent thrombotic complications of acute coronary syndromes and percutaneous coronary intervention. METHODS: To compare prasugrel, a new thienopyridine, with clopidogrel, we randomly assigned 13,608 patients with moderate-to-high-risk acute coronary syndromes with scheduled percutaneous coronary intervention to receive prasugrel (a 60-mg loading dose and a 10-mg daily maintenance dose) or clopidogrel (a 300-mg loading dose and a 75-mg daily maintenance dose), for 6 to 15 months. The primary efficacy end point was death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke. The key safety end point was major bleeding. RESULTS: The primary efficacy end point occurred in 12.1% of patients receiving clopidogrel and 9.9% of patients receiving prasugrel (hazard ratio for prasugrel vs. clopidogrel, 0.81; 95% confidence interval [CI], 0.73 to 0.90; P
AB - BACKGROUND: Dual-antiplatelet therapy with aspirin and a thienopyridine is a cornerstone of treatment to prevent thrombotic complications of acute coronary syndromes and percutaneous coronary intervention. METHODS: To compare prasugrel, a new thienopyridine, with clopidogrel, we randomly assigned 13,608 patients with moderate-to-high-risk acute coronary syndromes with scheduled percutaneous coronary intervention to receive prasugrel (a 60-mg loading dose and a 10-mg daily maintenance dose) or clopidogrel (a 300-mg loading dose and a 75-mg daily maintenance dose), for 6 to 15 months. The primary efficacy end point was death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke. The key safety end point was major bleeding. RESULTS: The primary efficacy end point occurred in 12.1% of patients receiving clopidogrel and 9.9% of patients receiving prasugrel (hazard ratio for prasugrel vs. clopidogrel, 0.81; 95% confidence interval [CI], 0.73 to 0.90; P
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U2 - 10.1056/NEJMoa0706482
DO - 10.1056/NEJMoa0706482
M3 - Article
C2 - 17982182
AN - SCOPUS:36148983750
VL - 357
SP - 2001
EP - 2015
JO - New England Journal of Medicine
JF - New England Journal of Medicine
SN - 0028-4793
IS - 20
ER -