Pravastatin reduces carotid intima-media thickness progression in an asymptomatic hypercholesterolemic Mediterranean population: The Carotid Atherosclerosis Italian Ultrasound Study

Michele Mercuri, M. Gene Bond, Cesare R. Sirtori, Fabrizio Veglia, Gaetano Crepaldi, F. Saverio Feruglio, Giancarlo Descovich, Giorgio Ricci, Paolo Rubba, Mario Mancini, Giuseppe Gallus, Giuseppe Bianchi, Gioacchino D'Alò, Alessandro Ventura

Research output: Contribution to journalArticle

Abstract

PURPOSE: The Carotid Atherosclerosis Italian Ultrasound Study (CAIUS) was performed to test the effects of lipid lowering on the progression of carotid intima-media thickness (IMT) in 305 asymptomatic patients from a Mediterranean country. PATIENTS AND METHODS: Eligibility included hypercholesterolemia (baseline means: low-density lipoprotein [LDL] = 4.68 mmol/L, high-density lipoprotein [HDL] = 1.37 mmol/L), and at least one 1.3 <IMT <3.5 mm in the carotid arteries. Patients (mean age 55 years, 53% male) were assigned to pravastatin (40 mg/day, n = 151) or placebo (n = 154). Ultrasound imaging was used to quantify IMT at baseline, and semiannually thereafter for up to 3 years. The mean of the 12 maximum IMTs (MMaxIMT), was calculated for each patient visit, and used to determine each patient's longitudinal progression slope. The intention-to-treat group difference in the MMaxIMT progression was chosen a priori as the primary end point. RESULTS: Five serious cardiovascular events (1 fatal myocardial infarction), and 7 drop-outs for cancer were registered. In the pravastatin group, LDL decreased -0.22 after 3 months versus -0.01 in the placebo group, and remained substantially unchanged afterward (-0.23 versus +0.01 at 36 months, respectively). Progression of the MMaxIMT was 0.009 ± 0.0027 versus -0.0043 ± 0.0028 mm/year (x̄ ± SE, P

Original languageEnglish
Pages (from-to)627-634
Number of pages8
JournalAmerican Journal of Medicine
Volume101
Issue number6
DOIs
Publication statusPublished - Dec 1996

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Pravastatin
Carotid Intima-Media Thickness
Carotid Artery Diseases
LDL Lipoproteins
Population
Placebos
HDL Lipoproteins
Hypercholesterolemia
Carotid Arteries
Ultrasonography
Myocardial Infarction
Lipids
Neoplasms

ASJC Scopus subject areas

  • Nursing(all)

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Pravastatin reduces carotid intima-media thickness progression in an asymptomatic hypercholesterolemic Mediterranean population : The Carotid Atherosclerosis Italian Ultrasound Study. / Mercuri, Michele; Bond, M. Gene; Sirtori, Cesare R.; Veglia, Fabrizio; Crepaldi, Gaetano; Feruglio, F. Saverio; Descovich, Giancarlo; Ricci, Giorgio; Rubba, Paolo; Mancini, Mario; Gallus, Giuseppe; Bianchi, Giuseppe; D'Alò, Gioacchino; Ventura, Alessandro.

In: American Journal of Medicine, Vol. 101, No. 6, 12.1996, p. 627-634.

Research output: Contribution to journalArticle

Mercuri, M, Bond, MG, Sirtori, CR, Veglia, F, Crepaldi, G, Feruglio, FS, Descovich, G, Ricci, G, Rubba, P, Mancini, M, Gallus, G, Bianchi, G, D'Alò, G & Ventura, A 1996, 'Pravastatin reduces carotid intima-media thickness progression in an asymptomatic hypercholesterolemic Mediterranean population: The Carotid Atherosclerosis Italian Ultrasound Study', American Journal of Medicine, vol. 101, no. 6, pp. 627-634. https://doi.org/10.1016/S0002-9343(96)00333-6
Mercuri, Michele ; Bond, M. Gene ; Sirtori, Cesare R. ; Veglia, Fabrizio ; Crepaldi, Gaetano ; Feruglio, F. Saverio ; Descovich, Giancarlo ; Ricci, Giorgio ; Rubba, Paolo ; Mancini, Mario ; Gallus, Giuseppe ; Bianchi, Giuseppe ; D'Alò, Gioacchino ; Ventura, Alessandro. / Pravastatin reduces carotid intima-media thickness progression in an asymptomatic hypercholesterolemic Mediterranean population : The Carotid Atherosclerosis Italian Ultrasound Study. In: American Journal of Medicine. 1996 ; Vol. 101, No. 6. pp. 627-634.
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T1 - Pravastatin reduces carotid intima-media thickness progression in an asymptomatic hypercholesterolemic Mediterranean population

T2 - The Carotid Atherosclerosis Italian Ultrasound Study

AU - Mercuri, Michele

AU - Bond, M. Gene

AU - Sirtori, Cesare R.

AU - Veglia, Fabrizio

AU - Crepaldi, Gaetano

AU - Feruglio, F. Saverio

AU - Descovich, Giancarlo

AU - Ricci, Giorgio

AU - Rubba, Paolo

AU - Mancini, Mario

AU - Gallus, Giuseppe

AU - Bianchi, Giuseppe

AU - D'Alò, Gioacchino

AU - Ventura, Alessandro

PY - 1996/12

Y1 - 1996/12

N2 - PURPOSE: The Carotid Atherosclerosis Italian Ultrasound Study (CAIUS) was performed to test the effects of lipid lowering on the progression of carotid intima-media thickness (IMT) in 305 asymptomatic patients from a Mediterranean country. PATIENTS AND METHODS: Eligibility included hypercholesterolemia (baseline means: low-density lipoprotein [LDL] = 4.68 mmol/L, high-density lipoprotein [HDL] = 1.37 mmol/L), and at least one 1.3 <IMT <3.5 mm in the carotid arteries. Patients (mean age 55 years, 53% male) were assigned to pravastatin (40 mg/day, n = 151) or placebo (n = 154). Ultrasound imaging was used to quantify IMT at baseline, and semiannually thereafter for up to 3 years. The mean of the 12 maximum IMTs (MMaxIMT), was calculated for each patient visit, and used to determine each patient's longitudinal progression slope. The intention-to-treat group difference in the MMaxIMT progression was chosen a priori as the primary end point. RESULTS: Five serious cardiovascular events (1 fatal myocardial infarction), and 7 drop-outs for cancer were registered. In the pravastatin group, LDL decreased -0.22 after 3 months versus -0.01 in the placebo group, and remained substantially unchanged afterward (-0.23 versus +0.01 at 36 months, respectively). Progression of the MMaxIMT was 0.009 ± 0.0027 versus -0.0043 ± 0.0028 mm/year (x̄ ± SE, P

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