Pravastatin reduces carotid intima-media thickness progression in an asymptomatic hypercholesterolemic Mediterranean population: The Carotid Atherosclerosis Italian Ultrasound Study

Michele Mercuri, M. Gene Bond, Cesare R. Sirtori, Fabrizio Veglia, Gaetano Crepaldi, F. Saverio Feruglio, Giancarlo Descovich, Giorgio Ricci, Paolo Rubba, Mario Mancini, Giuseppe Gallus, Giuseppe Bianchi, Gioacchino D'Alò, Alessandro Ventura

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Abstract

PURPOSE: The Carotid Atherosclerosis Italian Ultrasound Study (CAIUS) was performed to test the effects of lipid lowering on the progression of carotid intima-media thickness (IMT) in 305 asymptomatic patients from a Mediterranean country. PATIENTS AND METHODS: Eligibility included hypercholesterolemia (baseline means: low-density lipoprotein [LDL] = 4.68 mmol/L, high-density lipoprotein [HDL] = 1.37 mmol/L), and at least one 1.3 <IMT <3.5 mm in the carotid arteries. Patients (mean age 55 years, 53% male) were assigned to pravastatin (40 mg/day, n = 151) or placebo (n = 154). Ultrasound imaging was used to quantify IMT at baseline, and semiannually thereafter for up to 3 years. The mean of the 12 maximum IMTs (MMaxIMT), was calculated for each patient visit, and used to determine each patient's longitudinal progression slope. The intention-to-treat group difference in the MMaxIMT progression was chosen a priori as the primary end point. RESULTS: Five serious cardiovascular events (1 fatal myocardial infarction), and 7 drop-outs for cancer were registered. In the pravastatin group, LDL decreased -0.22 after 3 months versus -0.01 in the placebo group, and remained substantially unchanged afterward (-0.23 versus +0.01 at 36 months, respectively). Progression of the MMaxIMT was 0.009 ± 0.0027 versus -0.0043 ± 0.0028 mm/year (x̄ ± SE, P

Original languageEnglish
Pages (from-to)627-634
Number of pages8
JournalAmerican Journal of Medicine
Volume101
Issue number6
DOIs
Publication statusPublished - Dec 1996

ASJC Scopus subject areas

  • Nursing(all)

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