Pravastatin vs Gemfibrozil in the Treatment of Primary Hypercholesterolaemia

E. Malacco, Alberto Magni, L. Scandiani, A. Casini, S. Albano, R. Ansuini, T. Biasion, E. Biffi, G. Bilardo, G. Boccuzzi, E. Breda, A. Buttafarro, P. S. Chella, C. Chieffo, D. Coletta, L. Coli, L. Colombo, A. Compagnoni, G. D’Amico, C. D’AsciaM. De Gregori, U. De Joannon, R. Distante, V. Donadon, P. Donnini, F. Fallucca, L. Ferrari, E. Fesce, L. Formoso, M. Furlani, F. Galetta, R. Gianni, G. Giustina, L. Irace, A. Lipizer, F. Maggio, F. Magri, S. Mangiameli, S. Marasco, M. Marchetti, B. Marrazza, F. Melandri, G. Mondillo, M. Montagnani, C. Napoli, G. F. Neri, M. Orlandi, M. Pantaleoni, A. Papa, G. Perrella, V. Pileggi, G. P. Pilleri, M. Pittalis, M. Piva, F. Resta, T. Rodari, A. Savastano, M. Savona, S. Sensi, F. Sorrentino, S. Squadrito, C. Stocchiero, A. Stranieri, G. Susco, F. Tani, F. Tassone, R. Taverniti, P. F. Terrosu, G. Tirella, A. Vicario

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Abstract

An increase in total and low density lipoprotein (LDL) cholesterol concentrations is related to the incidence of cardiovascular heart disease. The purpose of this study was to compare the efficacy and safety of pravastatin, an HMG-CoA reductase inhibitor, versus gemfibrozil, a fibrate, in the treatment of primary hypercholesterolaemia. 855 subjects (males and females, aged between 18 and 70 years) with total cholesterol (TC) concentrations > 240 mg/dl and triglyceride (TG) concentrations <250 mg/dl were enrolled. After a pretreatment diet period, patients received either pravastatin 20 mg/day (659 patients) or gemfibrozil 1200 mg/day (196 patients). At the end of the 12-week treatment period, reductions in TC (−23%) and LDL-C (−31%) were noted in the pravastatin group. Gemfibrozil reduced TC by 16% and LDL by 20%. High density lipoprotein (HDL) cholesterol concentrations increased in a similar way in the two groups: pravastatin +10%, gemfibrozil+11%. Triglycerides decreased by 14% with pravastatin and by 22% with gemfibrozil. Pravastatin and gemfibrozil were both well tolerated. No significant adverse events or variations in laboratory parameters occurred during this study.

Original languageEnglish
Pages (from-to)331-339
Number of pages9
JournalDrug Investigation
Volume7
Issue number6
DOIs
Publication statusPublished - 1994

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ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Malacco, E., Magni, A., Scandiani, L., Casini, A., Albano, S., Ansuini, R., Biasion, T., Biffi, E., Bilardo, G., Boccuzzi, G., Breda, E., Buttafarro, A., Chella, P. S., Chieffo, C., Coletta, D., Coli, L., Colombo, L., Compagnoni, A., D’Amico, G., ... Vicario, A. (1994). Pravastatin vs Gemfibrozil in the Treatment of Primary Hypercholesterolaemia. Drug Investigation, 7(6), 331-339. https://doi.org/10.1007/BF03258475