pRb controls estrogen receptor alpha protein stability and activity

Isabella Caligiuri, Giuseppe Toffoli, Antonio Giordano, Flavio Rizzolio

Research output: Contribution to journalArticle

Abstract

A cross talk between the Estrogen Receptor (ESR1) and the Retinoblastoma (pRb) pathway has been demonstrated to influence the therapeutic response of breast cancer patients but the full mechanism remains poorly understood. Here we show that the N-terminal domain of pRb interacts with the CD domain of ESR1 to allow for the assembly of intermediate complex chaperone proteins HSP90 and p23. We demonstrated that a loss of pRb in human/mouse breast cells decreases the expression of the ESR1 protein through the proteasome pathway. Our work reveals a novel regulatory mechanism of ESR1 basal turnover and activity and an unanticipated relationship with the pRb tumor suppressor.

Original languageEnglish
Pages (from-to)875-883
Number of pages9
JournalOncotarget
Volume4
Issue number6
Publication statusPublished - Jun 2013

Keywords

  • Breast cancer
  • Chaperone proteins
  • Estrogen receptor alpha
  • Prb
  • Proteasome

ASJC Scopus subject areas

  • Oncology

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