Pre- and post-treatment patterns of human chorionic gonadotropin for early detection of persistence after a single dose of methotrexate for ectopic pregnancy

Andrea Natale, Massimo Candiani, Maurizio Barbieri, Chantal Calia, Maria P. Odorizzi, Mauro Busacca

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Objective: Given the great variability of human chorionic gonadotropin (HCG) levels after a single dose of methotrexate (MTX) for ectopic pregnancy, it remains complicated to identify cases undergoing persistence until a week from treatment. We evaluated whether pre-treatment patterns of HCG levels could be useful for an earlier detection of persistent trophoblast. Study design: A retrospective study on 62 patients treated by a systemic single dose of methotrexate (50 mg/m2) for an ectopic pregnancy. Samples for HCG detection were obtained on days -2 and 0 before the therapy, on days +3, +7 and then weekly until values were undetectable. Patients were divided into three groups: Group U (up, meaning "increasing") and Group D (down, meaning "decreasing") when HCG levels on day 0 were respectively higher or lower than day -2 level of more than 20% and Group P (plateau) when the difference between day -2 HCG level and the level on day 0 was less than 20%. Results: All the patients of Group D underwent a complete resolution, with a percentage of 33.3% of cases who underwent an initial rise of HCG levels on day +3. The percentage of cases undergoing an initial rise of HCG levels in Group U patients was significantly higher than in Group P patients (60.0% versus 28.6%), but the resolution rate resulted similar in the two groups. For patients of Group P, an increase of HCG levels on day +3 was significantly correlated to the failure of the therapy. Indeed, comparing the cases with an immediate increase of HCG levels to the cases with immediate decrease of HCG levels on day +3, the persistence rate was 80% for the former and 12% for the latter (P

Original languageEnglish
Pages (from-to)87-92
Number of pages6
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Volume117
Issue number1
DOIs
Publication statusPublished - Nov 10 2004

Fingerprint

Ectopic Pregnancy
Chorionic Gonadotropin
Methotrexate
Therapeutics
Trophoblasts
Retrospective Studies

Keywords

  • Ectopic pregnancy
  • HCG
  • Methotrexate
  • Persistence

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Pre- and post-treatment patterns of human chorionic gonadotropin for early detection of persistence after a single dose of methotrexate for ectopic pregnancy. / Natale, Andrea; Candiani, Massimo; Barbieri, Maurizio; Calia, Chantal; Odorizzi, Maria P.; Busacca, Mauro.

In: European Journal of Obstetrics and Gynecology and Reproductive Biology, Vol. 117, No. 1, 10.11.2004, p. 87-92.

Research output: Contribution to journalArticle

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abstract = "Objective: Given the great variability of human chorionic gonadotropin (HCG) levels after a single dose of methotrexate (MTX) for ectopic pregnancy, it remains complicated to identify cases undergoing persistence until a week from treatment. We evaluated whether pre-treatment patterns of HCG levels could be useful for an earlier detection of persistent trophoblast. Study design: A retrospective study on 62 patients treated by a systemic single dose of methotrexate (50 mg/m2) for an ectopic pregnancy. Samples for HCG detection were obtained on days -2 and 0 before the therapy, on days +3, +7 and then weekly until values were undetectable. Patients were divided into three groups: Group U (up, meaning {"}increasing{"}) and Group D (down, meaning {"}decreasing{"}) when HCG levels on day 0 were respectively higher or lower than day -2 level of more than 20{\%} and Group P (plateau) when the difference between day -2 HCG level and the level on day 0 was less than 20{\%}. Results: All the patients of Group D underwent a complete resolution, with a percentage of 33.3{\%} of cases who underwent an initial rise of HCG levels on day +3. The percentage of cases undergoing an initial rise of HCG levels in Group U patients was significantly higher than in Group P patients (60.0{\%} versus 28.6{\%}), but the resolution rate resulted similar in the two groups. For patients of Group P, an increase of HCG levels on day +3 was significantly correlated to the failure of the therapy. Indeed, comparing the cases with an immediate increase of HCG levels to the cases with immediate decrease of HCG levels on day +3, the persistence rate was 80{\%} for the former and 12{\%} for the latter (P",
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