Pre-clinical diagnosis of Alzheimer disease combining platelet amyloid precursor protein ratio and rCBF spect analysis

Barbara Borroni, Daniela Perani, Marcella Broli, Francesca Colciaghi, Valentina Garibotto, Barbara Paghera, Chiara Agosti, Raffaele Giubbini, Monica Di Luca, Alessandro Padovani

Research output: Contribution to journalArticle

Abstract

Platelet Amyloid Precursor Protein ratio of different abnormal forms and 99mTc-ECD SPECT perfusion analysis were evaluated in Mild Cognitive Impairment (MCI) subjects who progressed to Alzheimer Disease (AD) and in stable MCI. We report that their combined evaluation increases the discriminative power of the analysis in identifying presymptomatic AD. The positive predictive value of these combined markers in identifying progressive MCI was 0.87, and the negative predictive value was 0.90. This observation suggests that the interplay of different markers should be considered for enhancing diagnostic accuracy of pre-clinical AD.

Original languageEnglish
Pages (from-to)1359-1362
Number of pages4
JournalJournal of Neurology
Volume252
Issue number11
DOIs
Publication statusPublished - Nov 2005

Keywords

  • Alzheimer disease
  • Amyloid precursor protein
  • Mild cognitive impairment
  • Platelets
  • SPECT

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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    Borroni, B., Perani, D., Broli, M., Colciaghi, F., Garibotto, V., Paghera, B., Agosti, C., Giubbini, R., Di Luca, M., & Padovani, A. (2005). Pre-clinical diagnosis of Alzheimer disease combining platelet amyloid precursor protein ratio and rCBF spect analysis. Journal of Neurology, 252(11), 1359-1362. https://doi.org/10.1007/s00415-005-0867-z