Pre-clinical In Vitro and In Vivo Models for Heart Valve Therapies

Maurizio Taramasso, Maximilian Y. Emmert, Diana Reser, Andrea Guidotti, Nikola Cesarovic, Marino Campagnol, Alessandro Addis, Fabian Nietlispach, Simon P. Hoerstrup, Francesco Maisano

Research output: Contribution to journalArticlepeer-review

Abstract

Heart valve disease is a frequently encountered pathology, related to high morbidity and mortality rates. Animal models are interesting to investigate the causality but also underlying mechanisms and potential treatments of human heart valve diseases. Strongly believing that both in vivo and ex vivo models are fundamental to support research and development of new technologies, we here report some examples of heart valve disease models, which in our experience have been actively used to support the development of new valve therapies.

Original languageEnglish
Pages (from-to)319-327
Number of pages9
JournalJournal of Cardiovascular Translational Research
Volume8
Issue number5
DOIs
Publication statusPublished - May 13 2015

Keywords

  • Animal models
  • Bench model
  • Heart valve disease

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Genetics
  • Genetics(clinical)
  • Molecular Medicine
  • Pharmaceutical Science

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