Pre-clinical In Vitro and In Vivo Models for Heart Valve Therapies

Maurizio Taramasso; Maximilian Y. Emmert; Diana Reser; Andrea Guidotti; Nikola Cesarovic; Marino Campagnol; Alessandro Addis; Fabian Nietlispach; Simon P. Hoerstrup; Francesco Maisano

doi:10.1007/s12265-015-9631-7

Pre-clinical In Vitro and In Vivo Models for Heart Valve Therapies

Maurizio Taramasso, Maximilian Y. Emmert, Diana Reser, Andrea Guidotti, Nikola Cesarovic, Marino Campagnol, Alessandro Addis, Fabian Nietlispach, Simon P. Hoerstrup, Francesco Maisano

IRCCS Multimedica

Research output: Contribution to journal › Article › peer-review

Abstract

Heart valve disease is a frequently encountered pathology, related to high morbidity and mortality rates. Animal models are interesting to investigate the causality but also underlying mechanisms and potential treatments of human heart valve diseases. Strongly believing that both in vivo and ex vivo models are fundamental to support research and development of new technologies, we here report some examples of heart valve disease models, which in our experience have been actively used to support the development of new valve therapies.

Original language	English
Pages (from-to)	319-327
Number of pages	9
Journal	Journal of Cardiovascular Translational Research
Volume	8
Issue number	5
DOIs	https://doi.org/10.1007/s12265-015-9631-7
Publication status	Published - May 13 2015

Keywords

Animal models
Bench model
Heart valve disease

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Genetics
Genetics(clinical)
Molecular Medicine
Pharmaceutical Science

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10.1007/s12265-015-9631-7

Cite this

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abstract = "Heart valve disease is a frequently encountered pathology, related to high morbidity and mortality rates. Animal models are interesting to investigate the causality but also underlying mechanisms and potential treatments of human heart valve diseases. Strongly believing that both in vivo and ex vivo models are fundamental to support research and development of new technologies, we here report some examples of heart valve disease models, which in our experience have been actively used to support the development of new valve therapies.",

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AU - Taramasso, Maurizio

AU - Emmert, Maximilian Y.

AU - Reser, Diana

AU - Guidotti, Andrea

AU - Cesarovic, Nikola

AU - Campagnol, Marino

AU - Addis, Alessandro

AU - Nietlispach, Fabian

AU - Hoerstrup, Simon P.

AU - Maisano, Francesco

PY - 2015/5/13

Y1 - 2015/5/13

N2 - Heart valve disease is a frequently encountered pathology, related to high morbidity and mortality rates. Animal models are interesting to investigate the causality but also underlying mechanisms and potential treatments of human heart valve diseases. Strongly believing that both in vivo and ex vivo models are fundamental to support research and development of new technologies, we here report some examples of heart valve disease models, which in our experience have been actively used to support the development of new valve therapies.

AB - Heart valve disease is a frequently encountered pathology, related to high morbidity and mortality rates. Animal models are interesting to investigate the causality but also underlying mechanisms and potential treatments of human heart valve diseases. Strongly believing that both in vivo and ex vivo models are fundamental to support research and development of new technologies, we here report some examples of heart valve disease models, which in our experience have been actively used to support the development of new valve therapies.

KW - Animal models

KW - Bench model

KW - Heart valve disease

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Pre-clinical In Vitro and In Vivo Models for Heart Valve Therapies

Abstract

Keywords

ASJC Scopus subject areas

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