Pre-diagnostic anthropometry and survival after colorectal cancer diagnosis in Western European populations

Veronika Fedirko, Isabelle Romieu, Krasimira Aleksandrova, Tobias Pischon, Dimitrios Trichopoulos, Petra H. Peeters, Dora Romaguera-Bosch, H. B. Bueno-De-Mesquita, Christina C. Dahm, Kim Overvad, Maria Dolores Chirlaque, Christoffer Johansen, Pernille E. Bidstrup, Susanne O. Dalton, Marc J. Gunter, Petra A. Wark, Teresa Norat, Jytte Halkjær, Anne Tjønneland, Vincent K. DikPeter D. Siersema, Marie Christine Boutron-Ruault, Laure Dossus, Nadia Bastide, Tilman Kühn, Rudolf Kaaks, Heiner Boeing, Antonia Trichopoulou, Eleni Klinaki, Michalis Katsoulis, Valeria Pala, Salvatore Panico, Rosario Tumino, Domenico Palli, Paolo Vineis, Elisabete Weiderpass, Guri Skeie, Carlos A. González, María José Sánchez, Aurelio Barricarte, Pilar Amiano, J. Ramon Quiros, Jonas Manjer, Karin Jirström, Ingrid Ljuslinder, Richard Palmqvist, Kay Tee Khaw, Nick Wareham, Kathryn E. Bradbury, Magdalena Stepien, Talita Duarte-Salles, Elio Riboli, Mazda Jenab

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

General and abdominal adiposity are associated with a high risk of developing colorectal cancer (CRC), but the role of these exposures on cancer survival has been less studied. The association between pre-diagnostic anthropometric characteristics and CRC-specific and all-cause death was examined among 3,924 men and women diagnosed with CRC between 1992 and 2009 in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs). Over a mean follow-up period of 49 months, 1,309 deaths occurred of which 1,043 (79.7%) were due to CRC. In multivariable analysis, pre-diagnostic BMI ≥30 kg/m 2 was associated with a high risk for CRC-specific (HR = 1.26, 95% CI = 1.04-1.52) and all-cause (HR = 1.32, 95% CI = 1.12-1.56) death relative to BMI 2. Every 5 kg/m2 increase in BMI was associated with a high risk for CRC-specific (HR = 1.10, 95% CI = 1.02-1.19) and all-cause death (HR = 1.12, 95% CI = 1.05-1.20); and every 10 cm increase in waist circumference was associated with a high risk for CRC-specific (HR = 1.09, 95% CI = 1.02-1.16) and all-cause death (HR = 1.11, 95% CI = 1.05-1.18). Similar associations were observed for waist-to-hip and waist-to-height ratios. Height was not associated with CRC-specific or all-cause death. Associations tended to be stronger among men than in women. Possible interactions by age at diagnosis, cancer stage, tumour location, and hormone replacement therapy use among postmenopausal women were noted. Pre-diagnostic general and abdominal adiposity are associated with lower survival after CRC diagnosis.

Original languageEnglish
Pages (from-to)1949-1960
Number of pages12
JournalInternational Journal of Cancer
Volume135
Issue number8
DOIs
Publication statusPublished - Oct 15 2014

Fingerprint

Anthropometry
Colorectal Neoplasms
Survival
Confidence Intervals
Population
Cause of Death
Adiposity
Neoplasms
Hormone Replacement Therapy
Waist Circumference
Proportional Hazards Models
Hip

Keywords

  • abdominal obesity
  • body composition
  • colorectal neoplasms
  • obesity
  • survival

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Fedirko, V., Romieu, I., Aleksandrova, K., Pischon, T., Trichopoulos, D., Peeters, P. H., ... Jenab, M. (2014). Pre-diagnostic anthropometry and survival after colorectal cancer diagnosis in Western European populations. International Journal of Cancer, 135(8), 1949-1960. https://doi.org/10.1002/ijc.28841

Pre-diagnostic anthropometry and survival after colorectal cancer diagnosis in Western European populations. / Fedirko, Veronika; Romieu, Isabelle; Aleksandrova, Krasimira; Pischon, Tobias; Trichopoulos, Dimitrios; Peeters, Petra H.; Romaguera-Bosch, Dora; Bueno-De-Mesquita, H. B.; Dahm, Christina C.; Overvad, Kim; Chirlaque, Maria Dolores; Johansen, Christoffer; Bidstrup, Pernille E.; Dalton, Susanne O.; Gunter, Marc J.; Wark, Petra A.; Norat, Teresa; Halkjær, Jytte; Tjønneland, Anne; Dik, Vincent K.; Siersema, Peter D.; Boutron-Ruault, Marie Christine; Dossus, Laure; Bastide, Nadia; Kühn, Tilman; Kaaks, Rudolf; Boeing, Heiner; Trichopoulou, Antonia; Klinaki, Eleni; Katsoulis, Michalis; Pala, Valeria; Panico, Salvatore; Tumino, Rosario; Palli, Domenico; Vineis, Paolo; Weiderpass, Elisabete; Skeie, Guri; González, Carlos A.; Sánchez, María José; Barricarte, Aurelio; Amiano, Pilar; Quiros, J. Ramon; Manjer, Jonas; Jirström, Karin; Ljuslinder, Ingrid; Palmqvist, Richard; Khaw, Kay Tee; Wareham, Nick; Bradbury, Kathryn E.; Stepien, Magdalena; Duarte-Salles, Talita; Riboli, Elio; Jenab, Mazda.

In: International Journal of Cancer, Vol. 135, No. 8, 15.10.2014, p. 1949-1960.

Research output: Contribution to journalArticle

Fedirko, V, Romieu, I, Aleksandrova, K, Pischon, T, Trichopoulos, D, Peeters, PH, Romaguera-Bosch, D, Bueno-De-Mesquita, HB, Dahm, CC, Overvad, K, Chirlaque, MD, Johansen, C, Bidstrup, PE, Dalton, SO, Gunter, MJ, Wark, PA, Norat, T, Halkjær, J, Tjønneland, A, Dik, VK, Siersema, PD, Boutron-Ruault, MC, Dossus, L, Bastide, N, Kühn, T, Kaaks, R, Boeing, H, Trichopoulou, A, Klinaki, E, Katsoulis, M, Pala, V, Panico, S, Tumino, R, Palli, D, Vineis, P, Weiderpass, E, Skeie, G, González, CA, Sánchez, MJ, Barricarte, A, Amiano, P, Quiros, JR, Manjer, J, Jirström, K, Ljuslinder, I, Palmqvist, R, Khaw, KT, Wareham, N, Bradbury, KE, Stepien, M, Duarte-Salles, T, Riboli, E & Jenab, M 2014, 'Pre-diagnostic anthropometry and survival after colorectal cancer diagnosis in Western European populations', International Journal of Cancer, vol. 135, no. 8, pp. 1949-1960. https://doi.org/10.1002/ijc.28841
Fedirko V, Romieu I, Aleksandrova K, Pischon T, Trichopoulos D, Peeters PH et al. Pre-diagnostic anthropometry and survival after colorectal cancer diagnosis in Western European populations. International Journal of Cancer. 2014 Oct 15;135(8):1949-1960. https://doi.org/10.1002/ijc.28841
Fedirko, Veronika ; Romieu, Isabelle ; Aleksandrova, Krasimira ; Pischon, Tobias ; Trichopoulos, Dimitrios ; Peeters, Petra H. ; Romaguera-Bosch, Dora ; Bueno-De-Mesquita, H. B. ; Dahm, Christina C. ; Overvad, Kim ; Chirlaque, Maria Dolores ; Johansen, Christoffer ; Bidstrup, Pernille E. ; Dalton, Susanne O. ; Gunter, Marc J. ; Wark, Petra A. ; Norat, Teresa ; Halkjær, Jytte ; Tjønneland, Anne ; Dik, Vincent K. ; Siersema, Peter D. ; Boutron-Ruault, Marie Christine ; Dossus, Laure ; Bastide, Nadia ; Kühn, Tilman ; Kaaks, Rudolf ; Boeing, Heiner ; Trichopoulou, Antonia ; Klinaki, Eleni ; Katsoulis, Michalis ; Pala, Valeria ; Panico, Salvatore ; Tumino, Rosario ; Palli, Domenico ; Vineis, Paolo ; Weiderpass, Elisabete ; Skeie, Guri ; González, Carlos A. ; Sánchez, María José ; Barricarte, Aurelio ; Amiano, Pilar ; Quiros, J. Ramon ; Manjer, Jonas ; Jirström, Karin ; Ljuslinder, Ingrid ; Palmqvist, Richard ; Khaw, Kay Tee ; Wareham, Nick ; Bradbury, Kathryn E. ; Stepien, Magdalena ; Duarte-Salles, Talita ; Riboli, Elio ; Jenab, Mazda. / Pre-diagnostic anthropometry and survival after colorectal cancer diagnosis in Western European populations. In: International Journal of Cancer. 2014 ; Vol. 135, No. 8. pp. 1949-1960.
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abstract = "General and abdominal adiposity are associated with a high risk of developing colorectal cancer (CRC), but the role of these exposures on cancer survival has been less studied. The association between pre-diagnostic anthropometric characteristics and CRC-specific and all-cause death was examined among 3,924 men and women diagnosed with CRC between 1992 and 2009 in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs) and corresponding 95{\%} confidence intervals (CIs). Over a mean follow-up period of 49 months, 1,309 deaths occurred of which 1,043 (79.7{\%}) were due to CRC. In multivariable analysis, pre-diagnostic BMI ≥30 kg/m 2 was associated with a high risk for CRC-specific (HR = 1.26, 95{\%} CI = 1.04-1.52) and all-cause (HR = 1.32, 95{\%} CI = 1.12-1.56) death relative to BMI 2. Every 5 kg/m2 increase in BMI was associated with a high risk for CRC-specific (HR = 1.10, 95{\%} CI = 1.02-1.19) and all-cause death (HR = 1.12, 95{\%} CI = 1.05-1.20); and every 10 cm increase in waist circumference was associated with a high risk for CRC-specific (HR = 1.09, 95{\%} CI = 1.02-1.16) and all-cause death (HR = 1.11, 95{\%} CI = 1.05-1.18). Similar associations were observed for waist-to-hip and waist-to-height ratios. Height was not associated with CRC-specific or all-cause death. Associations tended to be stronger among men than in women. Possible interactions by age at diagnosis, cancer stage, tumour location, and hormone replacement therapy use among postmenopausal women were noted. Pre-diagnostic general and abdominal adiposity are associated with lower survival after CRC diagnosis.",
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AU - Fedirko, Veronika

AU - Romieu, Isabelle

AU - Aleksandrova, Krasimira

AU - Pischon, Tobias

AU - Trichopoulos, Dimitrios

AU - Peeters, Petra H.

AU - Romaguera-Bosch, Dora

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AU - Siersema, Peter D.

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AU - Dossus, Laure

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AU - Kühn, Tilman

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AU - Boeing, Heiner

AU - Trichopoulou, Antonia

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AU - Sánchez, María José

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AU - Quiros, J. Ramon

AU - Manjer, Jonas

AU - Jirström, Karin

AU - Ljuslinder, Ingrid

AU - Palmqvist, Richard

AU - Khaw, Kay Tee

AU - Wareham, Nick

AU - Bradbury, Kathryn E.

AU - Stepien, Magdalena

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AU - Riboli, Elio

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N2 - General and abdominal adiposity are associated with a high risk of developing colorectal cancer (CRC), but the role of these exposures on cancer survival has been less studied. The association between pre-diagnostic anthropometric characteristics and CRC-specific and all-cause death was examined among 3,924 men and women diagnosed with CRC between 1992 and 2009 in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs). Over a mean follow-up period of 49 months, 1,309 deaths occurred of which 1,043 (79.7%) were due to CRC. In multivariable analysis, pre-diagnostic BMI ≥30 kg/m 2 was associated with a high risk for CRC-specific (HR = 1.26, 95% CI = 1.04-1.52) and all-cause (HR = 1.32, 95% CI = 1.12-1.56) death relative to BMI 2. Every 5 kg/m2 increase in BMI was associated with a high risk for CRC-specific (HR = 1.10, 95% CI = 1.02-1.19) and all-cause death (HR = 1.12, 95% CI = 1.05-1.20); and every 10 cm increase in waist circumference was associated with a high risk for CRC-specific (HR = 1.09, 95% CI = 1.02-1.16) and all-cause death (HR = 1.11, 95% CI = 1.05-1.18). Similar associations were observed for waist-to-hip and waist-to-height ratios. Height was not associated with CRC-specific or all-cause death. Associations tended to be stronger among men than in women. Possible interactions by age at diagnosis, cancer stage, tumour location, and hormone replacement therapy use among postmenopausal women were noted. Pre-diagnostic general and abdominal adiposity are associated with lower survival after CRC diagnosis.

AB - General and abdominal adiposity are associated with a high risk of developing colorectal cancer (CRC), but the role of these exposures on cancer survival has been less studied. The association between pre-diagnostic anthropometric characteristics and CRC-specific and all-cause death was examined among 3,924 men and women diagnosed with CRC between 1992 and 2009 in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs). Over a mean follow-up period of 49 months, 1,309 deaths occurred of which 1,043 (79.7%) were due to CRC. In multivariable analysis, pre-diagnostic BMI ≥30 kg/m 2 was associated with a high risk for CRC-specific (HR = 1.26, 95% CI = 1.04-1.52) and all-cause (HR = 1.32, 95% CI = 1.12-1.56) death relative to BMI 2. Every 5 kg/m2 increase in BMI was associated with a high risk for CRC-specific (HR = 1.10, 95% CI = 1.02-1.19) and all-cause death (HR = 1.12, 95% CI = 1.05-1.20); and every 10 cm increase in waist circumference was associated with a high risk for CRC-specific (HR = 1.09, 95% CI = 1.02-1.16) and all-cause death (HR = 1.11, 95% CI = 1.05-1.18). Similar associations were observed for waist-to-hip and waist-to-height ratios. Height was not associated with CRC-specific or all-cause death. Associations tended to be stronger among men than in women. Possible interactions by age at diagnosis, cancer stage, tumour location, and hormone replacement therapy use among postmenopausal women were noted. Pre-diagnostic general and abdominal adiposity are associated with lower survival after CRC diagnosis.

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