Pre-diagnostic circulating insulin-like growth factor-I and bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition

Crystal Lin, Ruth C Travis, Paul N Appleby, Sarah Tipper, Elisabete Weiderpass, Jenny Chang-Claude, Inger T Gram, Rudolf Kaaks, Lambertus A Kiemeney, Börje Ljungberg, Rosario Tumino, Anne Tjønneland, Nina Roswall, Kim Overvad, Marie-Christine Boutron-Ruault, Francesca Romana Manciniveri, Gianluca Severi, Antonia Trichopoulou, Giovanna Masala, Carlotta SacerdoteClaudia Agnoli, Salvatore Panico, Bas Bueno-de-Mesquita, Petra H Peeters, Elena Salamanca-Fernández, Maria-Dolores Chirlaque, Eva Ardanaz, Miren Dorronsoro, Virginia Menéndez, Leila Luján-Barroso, Fredrik Liedberg, Heinz Freisling, Marc Gunter, Dagfinn Aune, Amanda J Cross, Elio Riboli, Timothy J Key, Aurora Perez-Cornago

Research output: Contribution to journalArticlepeer-review


Previous in vitro and case-control studies have found an association between the insulin-like growth factor (IGF)-axis and bladder cancer risk. Circulating concentrations of IGF-I have also been found to be associated with an increased risk of several cancer types; however, the relationship between pre-diagnostic circulating IGF-I concentrations and bladder cancer has never been studied prospectively. We investigated the association of pre-diagnostic plasma concentrations of IGF-I with risk of overall bladder cancer and urothelial cell carcinoma (UCC) in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 843 men and women diagnosed with bladder cancer between 1992 and 2005 were matched with 843 controls by recruitment centre, sex, age at recruitment, date of blood collection, duration of follow-up, time of day and fasting status at blood collection using an incidence density sampling protocol. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression with adjustment for smoking status. No association was found between pre-diagnostic circulating IGF-I concentration and overall bladder cancer risk (adjusted OR for highest versus lowest fourth: 0.91, 95% CI: 0.66-1.24, ptrend = 0.40) or UCC (n of cases = 776; 0.91, 0.65-1.26, ptrend = 0.40). There was no significant evidence of heterogeneity in the association of IGF-I with bladder cancer risk by tumour aggressiveness, sex, smoking status, or by time between blood collection and diagnosis (pheterogeneity > 0.05 for all). This first prospective study indicates no evidence of an association between plasma IGF-I concentrations and bladder cancer risk.

Original languageEnglish
Pages (from-to)2351-2358
Number of pages8
JournalInternational Journal of Cancer
Issue number10
Publication statusPublished - Nov 15 2018


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