Pre-diagnostic circulating insulin-like growth factor-I and bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition

Crystal Lin, Ruth C Travis, Paul N Appleby, Sarah Tipper, Elisabete Weiderpass, Jenny Chang-Claude, Inger T Gram, Rudolf Kaaks, Lambertus A Kiemeney, Börje Ljungberg, Rosario Tumino, Anne Tjønneland, Nina Roswall, Kim Overvad, Marie-Christine Boutron-Ruault, Francesca Romana Manciniveri, Gianluca Severi, Antonia Trichopoulou, Giovanna Masala, Carlotta SacerdoteClaudia Agnoli, Salvatore Panico, Bas Bueno-de-Mesquita, Petra H Peeters, Elena Salamanca-Fernández, Maria-Dolores Chirlaque, Eva Ardanaz, Miren Dorronsoro, Virginia Menéndez, Leila Luján-Barroso, Fredrik Liedberg, Heinz Freisling, Marc Gunter, Dagfinn Aune, Amanda J Cross, Elio Riboli, Timothy J Key, Aurora Perez-Cornago

Research output: Contribution to journalArticle

Abstract

Previous in vitro and case-control studies have found an association between the insulin-like growth factor (IGF)-axis and bladder cancer risk. Circulating concentrations of IGF-I have also been found to be associated with an increased risk of several cancer types; however, the relationship between pre-diagnostic circulating IGF-I concentrations and bladder cancer has never been studied prospectively. We investigated the association of pre-diagnostic plasma concentrations of IGF-I with risk of overall bladder cancer and urothelial cell carcinoma (UCC) in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 843 men and women diagnosed with bladder cancer between 1992 and 2005 were matched with 843 controls by recruitment centre, sex, age at recruitment, date of blood collection, duration of follow-up, time of day and fasting status at blood collection using an incidence density sampling protocol. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression with adjustment for smoking status. No association was found between pre-diagnostic circulating IGF-I concentration and overall bladder cancer risk (adjusted OR for highest versus lowest fourth: 0.91, 95% CI: 0.66-1.24, ptrend = 0.40) or UCC (n of cases = 776; 0.91, 0.65-1.26, ptrend = 0.40). There was no significant evidence of heterogeneity in the association of IGF-I with bladder cancer risk by tumour aggressiveness, sex, smoking status, or by time between blood collection and diagnosis (pheterogeneity > 0.05 for all). This first prospective study indicates no evidence of an association between plasma IGF-I concentrations and bladder cancer risk.

Original languageEnglish
Pages (from-to)2351-2358
Number of pages8
JournalInternational Journal of Cancer
Volume143
Issue number10
DOIs
Publication statusPublished - Nov 15 2018

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Insulin-Like Growth Factor I
Urinary Bladder Neoplasms
Neoplasms
Case-Control Studies
Smoking
Odds Ratio
Confidence Intervals
Carcinoma
Somatomedins
Fasting
Logistic Models
Prospective Studies
Incidence

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Pre-diagnostic circulating insulin-like growth factor-I and bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition. / Lin, Crystal; Travis, Ruth C; Appleby, Paul N; Tipper, Sarah; Weiderpass, Elisabete; Chang-Claude, Jenny; Gram, Inger T; Kaaks, Rudolf; Kiemeney, Lambertus A; Ljungberg, Börje; Tumino, Rosario; Tjønneland, Anne; Roswall, Nina; Overvad, Kim; Boutron-Ruault, Marie-Christine; Manciniveri, Francesca Romana; Severi, Gianluca; Trichopoulou, Antonia; Masala, Giovanna; Sacerdote, Carlotta; Agnoli, Claudia; Panico, Salvatore; Bueno-de-Mesquita, Bas; Peeters, Petra H; Salamanca-Fernández, Elena; Chirlaque, Maria-Dolores; Ardanaz, Eva; Dorronsoro, Miren; Menéndez, Virginia; Luján-Barroso, Leila; Liedberg, Fredrik; Freisling, Heinz; Gunter, Marc; Aune, Dagfinn; Cross, Amanda J; Riboli, Elio; Key, Timothy J; Perez-Cornago, Aurora.

In: International Journal of Cancer, Vol. 143, No. 10, 15.11.2018, p. 2351-2358.

Research output: Contribution to journalArticle

Lin, C, Travis, RC, Appleby, PN, Tipper, S, Weiderpass, E, Chang-Claude, J, Gram, IT, Kaaks, R, Kiemeney, LA, Ljungberg, B, Tumino, R, Tjønneland, A, Roswall, N, Overvad, K, Boutron-Ruault, M-C, Manciniveri, FR, Severi, G, Trichopoulou, A, Masala, G, Sacerdote, C, Agnoli, C, Panico, S, Bueno-de-Mesquita, B, Peeters, PH, Salamanca-Fernández, E, Chirlaque, M-D, Ardanaz, E, Dorronsoro, M, Menéndez, V, Luján-Barroso, L, Liedberg, F, Freisling, H, Gunter, M, Aune, D, Cross, AJ, Riboli, E, Key, TJ & Perez-Cornago, A 2018, 'Pre-diagnostic circulating insulin-like growth factor-I and bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition', International Journal of Cancer, vol. 143, no. 10, pp. 2351-2358. https://doi.org/10.1002/ijc.31650
Lin, Crystal ; Travis, Ruth C ; Appleby, Paul N ; Tipper, Sarah ; Weiderpass, Elisabete ; Chang-Claude, Jenny ; Gram, Inger T ; Kaaks, Rudolf ; Kiemeney, Lambertus A ; Ljungberg, Börje ; Tumino, Rosario ; Tjønneland, Anne ; Roswall, Nina ; Overvad, Kim ; Boutron-Ruault, Marie-Christine ; Manciniveri, Francesca Romana ; Severi, Gianluca ; Trichopoulou, Antonia ; Masala, Giovanna ; Sacerdote, Carlotta ; Agnoli, Claudia ; Panico, Salvatore ; Bueno-de-Mesquita, Bas ; Peeters, Petra H ; Salamanca-Fernández, Elena ; Chirlaque, Maria-Dolores ; Ardanaz, Eva ; Dorronsoro, Miren ; Menéndez, Virginia ; Luján-Barroso, Leila ; Liedberg, Fredrik ; Freisling, Heinz ; Gunter, Marc ; Aune, Dagfinn ; Cross, Amanda J ; Riboli, Elio ; Key, Timothy J ; Perez-Cornago, Aurora. / Pre-diagnostic circulating insulin-like growth factor-I and bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition. In: International Journal of Cancer. 2018 ; Vol. 143, No. 10. pp. 2351-2358.
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abstract = "Previous in vitro and case-control studies have found an association between the insulin-like growth factor (IGF)-axis and bladder cancer risk. Circulating concentrations of IGF-I have also been found to be associated with an increased risk of several cancer types; however, the relationship between pre-diagnostic circulating IGF-I concentrations and bladder cancer has never been studied prospectively. We investigated the association of pre-diagnostic plasma concentrations of IGF-I with risk of overall bladder cancer and urothelial cell carcinoma (UCC) in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 843 men and women diagnosed with bladder cancer between 1992 and 2005 were matched with 843 controls by recruitment centre, sex, age at recruitment, date of blood collection, duration of follow-up, time of day and fasting status at blood collection using an incidence density sampling protocol. Odds ratios (ORs) and 95{\%} confidence intervals (CIs) were calculated using conditional logistic regression with adjustment for smoking status. No association was found between pre-diagnostic circulating IGF-I concentration and overall bladder cancer risk (adjusted OR for highest versus lowest fourth: 0.91, 95{\%} CI: 0.66-1.24, ptrend = 0.40) or UCC (n of cases = 776; 0.91, 0.65-1.26, ptrend = 0.40). There was no significant evidence of heterogeneity in the association of IGF-I with bladder cancer risk by tumour aggressiveness, sex, smoking status, or by time between blood collection and diagnosis (pheterogeneity > 0.05 for all). This first prospective study indicates no evidence of an association between plasma IGF-I concentrations and bladder cancer risk.",
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T1 - Pre-diagnostic circulating insulin-like growth factor-I and bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition

AU - Lin, Crystal

AU - Travis, Ruth C

AU - Appleby, Paul N

AU - Tipper, Sarah

AU - Weiderpass, Elisabete

AU - Chang-Claude, Jenny

AU - Gram, Inger T

AU - Kaaks, Rudolf

AU - Kiemeney, Lambertus A

AU - Ljungberg, Börje

AU - Tumino, Rosario

AU - Tjønneland, Anne

AU - Roswall, Nina

AU - Overvad, Kim

AU - Boutron-Ruault, Marie-Christine

AU - Manciniveri, Francesca Romana

AU - Severi, Gianluca

AU - Trichopoulou, Antonia

AU - Masala, Giovanna

AU - Sacerdote, Carlotta

AU - Agnoli, Claudia

AU - Panico, Salvatore

AU - Bueno-de-Mesquita, Bas

AU - Peeters, Petra H

AU - Salamanca-Fernández, Elena

AU - Chirlaque, Maria-Dolores

AU - Ardanaz, Eva

AU - Dorronsoro, Miren

AU - Menéndez, Virginia

AU - Luján-Barroso, Leila

AU - Liedberg, Fredrik

AU - Freisling, Heinz

AU - Gunter, Marc

AU - Aune, Dagfinn

AU - Cross, Amanda J

AU - Riboli, Elio

AU - Key, Timothy J

AU - Perez-Cornago, Aurora

N1 - © 2018 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.

PY - 2018/11/15

Y1 - 2018/11/15

N2 - Previous in vitro and case-control studies have found an association between the insulin-like growth factor (IGF)-axis and bladder cancer risk. Circulating concentrations of IGF-I have also been found to be associated with an increased risk of several cancer types; however, the relationship between pre-diagnostic circulating IGF-I concentrations and bladder cancer has never been studied prospectively. We investigated the association of pre-diagnostic plasma concentrations of IGF-I with risk of overall bladder cancer and urothelial cell carcinoma (UCC) in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 843 men and women diagnosed with bladder cancer between 1992 and 2005 were matched with 843 controls by recruitment centre, sex, age at recruitment, date of blood collection, duration of follow-up, time of day and fasting status at blood collection using an incidence density sampling protocol. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression with adjustment for smoking status. No association was found between pre-diagnostic circulating IGF-I concentration and overall bladder cancer risk (adjusted OR for highest versus lowest fourth: 0.91, 95% CI: 0.66-1.24, ptrend = 0.40) or UCC (n of cases = 776; 0.91, 0.65-1.26, ptrend = 0.40). There was no significant evidence of heterogeneity in the association of IGF-I with bladder cancer risk by tumour aggressiveness, sex, smoking status, or by time between blood collection and diagnosis (pheterogeneity > 0.05 for all). This first prospective study indicates no evidence of an association between plasma IGF-I concentrations and bladder cancer risk.

AB - Previous in vitro and case-control studies have found an association between the insulin-like growth factor (IGF)-axis and bladder cancer risk. Circulating concentrations of IGF-I have also been found to be associated with an increased risk of several cancer types; however, the relationship between pre-diagnostic circulating IGF-I concentrations and bladder cancer has never been studied prospectively. We investigated the association of pre-diagnostic plasma concentrations of IGF-I with risk of overall bladder cancer and urothelial cell carcinoma (UCC) in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 843 men and women diagnosed with bladder cancer between 1992 and 2005 were matched with 843 controls by recruitment centre, sex, age at recruitment, date of blood collection, duration of follow-up, time of day and fasting status at blood collection using an incidence density sampling protocol. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression with adjustment for smoking status. No association was found between pre-diagnostic circulating IGF-I concentration and overall bladder cancer risk (adjusted OR for highest versus lowest fourth: 0.91, 95% CI: 0.66-1.24, ptrend = 0.40) or UCC (n of cases = 776; 0.91, 0.65-1.26, ptrend = 0.40). There was no significant evidence of heterogeneity in the association of IGF-I with bladder cancer risk by tumour aggressiveness, sex, smoking status, or by time between blood collection and diagnosis (pheterogeneity > 0.05 for all). This first prospective study indicates no evidence of an association between plasma IGF-I concentrations and bladder cancer risk.

U2 - 10.1002/ijc.31650

DO - 10.1002/ijc.31650

M3 - Article

C2 - 29971779

VL - 143

SP - 2351

EP - 2358

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 10

ER -