Pre-eclampsia onset and SPARC: A possible involvement in placenta development

Giovanni Tossetta; Sonia Fantone; Stefano R Giannubilo; Elena Marinelli Busilacchi; Andrea Ciavattini; Mario Castellucci; Nicoletta Di Simone; Monica Mattioli-Belmonte; Daniela Marzioni

doi:10.1002/jcp.27344

Pre-eclampsia onset and SPARC: A possible involvement in placenta development

Giovanni Tossetta, Sonia Fantone, Stefano R Giannubilo, Elena Marinelli Busilacchi, Andrea Ciavattini, Mario Castellucci, Nicoletta Di Simone, Monica Mattioli-Belmonte, Daniela Marzioni

IRCCS Fondazione Policlinico Universitario A. Gemelli

Research output: Contribution to journal › Article › peer-review

Abstract

Pre-eclampsia (PE) is a multisystem disorder commonly diagnosed in the latter half of pregnancy and it is a leading cause of intrauterine fetal growth retardation (IUGR). The aim of this study was to investigate the localization and the role of SPARC, secreted protein acidic, and rich in cysteine, in PE and PE-IUGR placentas in comparison with normal placentas. SPARC was mainly expressed in the villous and extravillous cytotrophoblastic cells in first trimester, whereas in PE, PE-IUGR and at term placentas, SPARC immunostaining was visible in both cytotrophoblastic cells and syncytiotrophoblast. SPARC expression significantly decreased in normal placenta from first to third trimester and a further significant reduction was demonstrated in PE and PE-IUGR. The latter downregulation of SPARC depends on hypoxic condition as shown by in vitro models. In conclusion, SPARC can play a pivotal role in PE and PE-IUGR onset and it should be considered as a key molecule for future investigations in such pathologies.

Original language	English
Pages (from-to)	6091-6098
Number of pages	8
Journal	Journal of Cellular Physiology
Volume	234
Issue number	5
DOIs	https://doi.org/10.1002/jcp.27344
Publication status	Published - May 2019

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Pre-eclampsia onset and SPARC : A possible involvement in placenta development. / Tossetta, Giovanni; Fantone, Sonia; Giannubilo, Stefano R; Marinelli Busilacchi, Elena; Ciavattini, Andrea; Castellucci, Mario; Di Simone, Nicoletta; Mattioli-Belmonte, Monica; Marzioni, Daniela.

In: Journal of Cellular Physiology, Vol. 234, No. 5, 05.2019, p. 6091-6098.

Research output: Contribution to journal › Article › peer-review

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abstract = "Pre-eclampsia (PE) is a multisystem disorder commonly diagnosed in the latter half of pregnancy and it is a leading cause of intrauterine fetal growth retardation (IUGR). The aim of this study was to investigate the localization and the role of SPARC, secreted protein acidic, and rich in cysteine, in PE and PE-IUGR placentas in comparison with normal placentas. SPARC was mainly expressed in the villous and extravillous cytotrophoblastic cells in first trimester, whereas in PE, PE-IUGR and at term placentas, SPARC immunostaining was visible in both cytotrophoblastic cells and syncytiotrophoblast. SPARC expression significantly decreased in normal placenta from first to third trimester and a further significant reduction was demonstrated in PE and PE-IUGR. The latter downregulation of SPARC depends on hypoxic condition as shown by in vitro models. In conclusion, SPARC can play a pivotal role in PE and PE-IUGR onset and it should be considered as a key molecule for future investigations in such pathologies.",

author = "Giovanni Tossetta and Sonia Fantone and Giannubilo, {Stefano R} and {Marinelli Busilacchi}, Elena and Andrea Ciavattini and Mario Castellucci and {Di Simone}, Nicoletta and Monica Mattioli-Belmonte and Daniela Marzioni",

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AU - Tossetta, Giovanni

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AU - Giannubilo, Stefano R

AU - Marinelli Busilacchi, Elena

AU - Ciavattini, Andrea

AU - Castellucci, Mario

AU - Di Simone, Nicoletta

AU - Mattioli-Belmonte, Monica

AU - Marzioni, Daniela

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