Pre-operative Redox State Affects 1-Month Survival in Patients With Advanced Heart Failure Undergoing Left Ventricular Assist Device Implantation

Raffaele Caruso, Andrea Garatti, Valentina Sedda, Filippo Milazzo, Jonica Campolo, Tiziano Colombo, Emanuele Catena, Giuliana Cighetti, Claudio Russo, Maria Frigerio, Ettore Vitali, Oberdan Parodi

Research output: Contribution to journalArticle

Abstract

Background: Left ventricular assist device (LVAD) implantation has proven effective as a bridge to transplantation in end-stage heart failure patients (ESHFPs), although survival during device support is critical. Oxidative stress has been implicated in the development of heart failure, but the influence of redox state on in-hospital post-LVAD outcome has not been clarified. Methods and Results: In this report we describe the oxidant/anti-oxidant profiles of 15 ESHFPs before LVAD placement, 5 of whom did not survive to 1 month, and in 30 subjects without cardiac disease, representing the control group. Conclusions: Preliminary findings suggest that adequate activity of the GPx-1-based anti-oxidant system before device placement is associated with patient survival up to 1 month, despite comparable baseline oxidative stress in patients who both survived and died (within 2 weeks post-LVAD).

Original languageEnglish
Pages (from-to)1177-1181
Number of pages5
JournalJournal of Heart and Lung Transplantation
Volume26
Issue number11
DOIs
Publication statusPublished - Nov 2007

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Transplantation

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    Caruso, R., Garatti, A., Sedda, V., Milazzo, F., Campolo, J., Colombo, T., Catena, E., Cighetti, G., Russo, C., Frigerio, M., Vitali, E., & Parodi, O. (2007). Pre-operative Redox State Affects 1-Month Survival in Patients With Advanced Heart Failure Undergoing Left Ventricular Assist Device Implantation. Journal of Heart and Lung Transplantation, 26(11), 1177-1181. https://doi.org/10.1016/j.healun.2007.07.009