Pre-treatment neutrophil-to-lymphocyte ratio may be associated with the outcome in patients treated with everolimus for metastatic renal cell carcinoma

M. Santoni; U. De Giorgi; R. Iacovelli; A. Conti; L. Burattini; L. Rossi; S. Luca Burgio; R. Berardi; G. Muzzonigro; E. Cortesi; D. Amadori; S. Cascinu

doi:10.1038/bjc.2013.522

Pre-treatment neutrophil-to-lymphocyte ratio may be associated with the outcome in patients treated with everolimus for metastatic renal cell carcinoma

M. Santoni, U. De Giorgi, R. Iacovelli, A. Conti, L. Burattini, L. Rossi, S. Luca Burgio, R. Berardi, G. Muzzonigro, E. Cortesi, D. Amadori, S. Cascinu

Research output: Contribution to journal › Article › peer-review

Abstract

Background:Everolimus is a mammalian target of rapamycin inhibitor approved for the treatment of metastatic renal cell carcinoma (mRCC). We aimed to assess the association between pre-treatment neutrophil-to-lymphocyte ratio (NLR) and the outcome of patients treated with everolimus for mRCC.Methods:Ninety-seven patients with mRCC were treated with everolimus till April 2013 in our institutions. Patients were stratified in two groups with NLR >3 (Group A) vs

Original language	English
Pages (from-to)	1755-1759
Number of pages	5
Journal	British Journal of Cancer
Volume	109
Issue number	7
DOIs	https://doi.org/10.1038/bjc.2013.522
Publication status	Published - Oct 1 2013

Keywords

everolimus
mTOR inhibitors
neutrophil-tolymphocyte ratio
renal cell carcinoma
targeted therapy
tyrosine kinase inhibitor

ASJC Scopus subject areas

Cancer Research
Oncology

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Santoni, M., De Giorgi, U., Iacovelli, R., Conti, A., Burattini, L., Rossi, L., Luca Burgio, S., Berardi, R., Muzzonigro, G., Cortesi, E., Amadori, D., & Cascinu, S. (2013). Pre-treatment neutrophil-to-lymphocyte ratio may be associated with the outcome in patients treated with everolimus for metastatic renal cell carcinoma. British Journal of Cancer, 109(7), 1755-1759. https://doi.org/10.1038/bjc.2013.522

Pre-treatment neutrophil-to-lymphocyte ratio may be associated with the outcome in patients treated with everolimus for metastatic renal cell carcinoma. / Santoni, M.; De Giorgi, U.; Iacovelli, R.; Conti, A.; Burattini, L.; Rossi, L.; Luca Burgio, S.; Berardi, R.; Muzzonigro, G.; Cortesi, E.; Amadori, D.; Cascinu, S.

In: British Journal of Cancer, Vol. 109, No. 7, 01.10.2013, p. 1755-1759.

Research output: Contribution to journal › Article › peer-review

Santoni, M, De Giorgi, U , Iacovelli, R, Conti, A, Burattini, L, Rossi, L, Luca Burgio, S, Berardi, R, Muzzonigro, G, Cortesi, E, Amadori, D & Cascinu, S 2013, 'Pre-treatment neutrophil-to-lymphocyte ratio may be associated with the outcome in patients treated with everolimus for metastatic renal cell carcinoma', British Journal of Cancer, vol. 109, no. 7, pp. 1755-1759. https://doi.org/10.1038/bjc.2013.522

Santoni, M. ; De Giorgi, U. ; Iacovelli, R. ; Conti, A. ; Burattini, L. ; Rossi, L. ; Luca Burgio, S. ; Berardi, R. ; Muzzonigro, G. ; Cortesi, E. ; Amadori, D. ; Cascinu, S. / Pre-treatment neutrophil-to-lymphocyte ratio may be associated with the outcome in patients treated with everolimus for metastatic renal cell carcinoma. In: British Journal of Cancer. 2013 ; Vol. 109, No. 7. pp. 1755-1759.

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