TY - JOUR
T1 - Preamyloid deposits in the cerebral cortex of patients with Alzheimer's disease and nondemented individuals
AU - Tagliavini, Fabrizio
AU - Giaccone, Giorgio
AU - Frangione, Blas
AU - Bugiani, Orso
PY - 1988/11/11
Y1 - 1988/11/11
N2 - A polyclonal antibody to a 28 residue synthetic peptide, homologous to the NH2 terminal region of amyloid β-protein, was employed in a study of the frontal and temporal cortex of 8 Alzheimer patients and 13 non-demented individuals aimed to define the relationship of immunolabelled to argyrophilic, congophilic and thioflavine S-positive cortical lesions. In Alzheimer patients, this antiserum labelled not only senile plaques and congophilic angiopathy, but also cortical deposits that were neither argyrophilic, congophilic nor thioflavine S-positive and were unrelated to degenerating neurites, tangle-bearing neurons or congophilic angiopathy. Similar lesions were observed in 4 of 13 non-demented individuals, in the absence of tangles, plaques or congophilic angiopathy, and in one in association with plaques. Such deposits might have been due to amyloid precursors still lacking the β-pleated sheet molecular conformation responsible for amyloid tinctorial and optical properties.
AB - A polyclonal antibody to a 28 residue synthetic peptide, homologous to the NH2 terminal region of amyloid β-protein, was employed in a study of the frontal and temporal cortex of 8 Alzheimer patients and 13 non-demented individuals aimed to define the relationship of immunolabelled to argyrophilic, congophilic and thioflavine S-positive cortical lesions. In Alzheimer patients, this antiserum labelled not only senile plaques and congophilic angiopathy, but also cortical deposits that were neither argyrophilic, congophilic nor thioflavine S-positive and were unrelated to degenerating neurites, tangle-bearing neurons or congophilic angiopathy. Similar lesions were observed in 4 of 13 non-demented individuals, in the absence of tangles, plaques or congophilic angiopathy, and in one in association with plaques. Such deposits might have been due to amyloid precursors still lacking the β-pleated sheet molecular conformation responsible for amyloid tinctorial and optical properties.
KW - Alzheimer's disease
KW - Amyloid
KW - Congophilic angiopathy
KW - Immunohistochemistry
KW - Senile plaque
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U2 - 10.1016/0304-3940(88)90080-8
DO - 10.1016/0304-3940(88)90080-8
M3 - Article
C2 - 3241644
AN - SCOPUS:0023798449
VL - 93
SP - 191
EP - 196
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 2-3
ER -