Preamyloid deposits in the cerebral cortex of patients with Alzheimer's disease and nondemented individuals

Fabrizio Tagliavini, Giorgio Giaccone, Blas Frangione, Orso Bugiani

Research output: Contribution to journalArticle

Abstract

A polyclonal antibody to a 28 residue synthetic peptide, homologous to the NH2 terminal region of amyloid β-protein, was employed in a study of the frontal and temporal cortex of 8 Alzheimer patients and 13 non-demented individuals aimed to define the relationship of immunolabelled to argyrophilic, congophilic and thioflavine S-positive cortical lesions. In Alzheimer patients, this antiserum labelled not only senile plaques and congophilic angiopathy, but also cortical deposits that were neither argyrophilic, congophilic nor thioflavine S-positive and were unrelated to degenerating neurites, tangle-bearing neurons or congophilic angiopathy. Similar lesions were observed in 4 of 13 non-demented individuals, in the absence of tangles, plaques or congophilic angiopathy, and in one in association with plaques. Such deposits might have been due to amyloid precursors still lacking the β-pleated sheet molecular conformation responsible for amyloid tinctorial and optical properties.

Original languageEnglish
Pages (from-to)191-196
Number of pages6
JournalNeuroscience Letters
Volume93
Issue number2-3
DOIs
Publication statusPublished - Nov 11 1988

Keywords

  • Alzheimer's disease
  • Amyloid
  • Congophilic angiopathy
  • Immunohistochemistry
  • Senile plaque

ASJC Scopus subject areas

  • Neuroscience(all)

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