TY - JOUR
T1 - Precancerous lesions of the stomach, gastric cancer and hereditary gastric cancer syndromes
AU - Gullo, Irene
AU - Grillo, Federica
AU - Mastracci, Luca
AU - Vanoli, Alessandro
AU - Carneiro, Fatima
AU - Saragoni, Luca
AU - Limarzi, Francesco
AU - Ferro, Jacopo
AU - Parente, Paola
AU - Fassan, Matteo
N1 - Publisher Copyright:
Copyright © 2020 Società Italiana di Anatomia Patologica e Citopatologia Diagnostica, Divisione Italiana della International Academy of Pathology.
Copyright:
This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine
PY - 2020/9/1
Y1 - 2020/9/1
N2 - Gastric cancer accounts for about 6% of cancers worldwide, being the fifth most frequently diagnosed malignancy and the third leading cause of cancer related death. Gastric carcinogenesis is a multistep and multifactorial process and is the result of the complex interplay between genetic susceptibility and environmental factors. The identification of predisposing conditions and of precancerous lesions is the basis for screening programs and early stage treatment. Furthermore, although most gastric cancers are sporadic, familial clustering is observed in up to 10% of patients. Among them, hereditary cases, related to known cancer susceptibility syndromes and/or genetic causes are thought to account for 1-3% of all gastric cancers. The pathology report of gastric resections specimens therefore requires a standardized approach as well as in depth knowledge of prognostic and treatment associated factors.
AB - Gastric cancer accounts for about 6% of cancers worldwide, being the fifth most frequently diagnosed malignancy and the third leading cause of cancer related death. Gastric carcinogenesis is a multistep and multifactorial process and is the result of the complex interplay between genetic susceptibility and environmental factors. The identification of predisposing conditions and of precancerous lesions is the basis for screening programs and early stage treatment. Furthermore, although most gastric cancers are sporadic, familial clustering is observed in up to 10% of patients. Among them, hereditary cases, related to known cancer susceptibility syndromes and/or genetic causes are thought to account for 1-3% of all gastric cancers. The pathology report of gastric resections specimens therefore requires a standardized approach as well as in depth knowledge of prognostic and treatment associated factors.
KW - gastric adenocarcinoma
KW - gastric cancer
KW - gastric dysplasia
KW - hereditary diffuse gastric cancer (HDGC)
KW - hereditary gastric cancer syndromes
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U2 - 10.32074/1591-951X-166
DO - 10.32074/1591-951X-166
M3 - Review article
C2 - 33179620
AN - SCOPUS:85096081649
VL - 112
SP - 166
EP - 185
JO - Pathologica
JF - Pathologica
SN - 0031-2983
IS - 3
ER -