Abstract
Precipitating antibodies have been found in 3 polytransfused patients with severe homozygous VWD. Such antibodies seem to be mainly directed towards Willebrand factor and factor VIII related antigen (VIII:AG) rather than towards factor VIII clotting activity (VIII:C). Since VIII:C may reside on a separate molecule linked by non convalent bonds to VIIIR:AG, it remains to be demonstrated whether the partial neutralization of VIII:C is specific or secondary to steric hindrance.
Original language | English |
---|---|
Pages (from-to) | 141-142 |
Number of pages | 2 |
Journal | Nature |
Volume | 262 |
Issue number | 5564 |
DOIs | |
Publication status | Published - 1976 |
ASJC Scopus subject areas
- General