Precipitating antibodies in von Willebrand's disease

P. M. Mannucci; D. Meyer; Z. M. Ruggeri; J. Koutts; N. Ciavarella; J. M. Lavergne

doi:10.1038/262141a0

Precipitating antibodies in von Willebrand's disease

P. M. Mannucci, D. Meyer, Z. M. Ruggeri, J. Koutts, N. Ciavarella, J. M. Lavergne

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

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Abstract

Precipitating antibodies have been found in 3 polytransfused patients with severe homozygous VWD. Such antibodies seem to be mainly directed towards Willebrand factor and factor VIII related antigen (VIII:AG) rather than towards factor VIII clotting activity (VIII:C). Since VIII:C may reside on a separate molecule linked by non convalent bonds to VIIIR:AG, it remains to be demonstrated whether the partial neutralization of VIII:C is specific or secondary to steric hindrance.

Original language	English
Pages (from-to)	141-142
Number of pages	2
Journal	Nature
Volume	262
Issue number	5564
DOIs	https://doi.org/10.1038/262141a0
Publication status	Published - 1976

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title = "Precipitating antibodies in von Willebrand's disease",

abstract = "Precipitating antibodies have been found in 3 polytransfused patients with severe homozygous VWD. Such antibodies seem to be mainly directed towards Willebrand factor and factor VIII related antigen (VIII:AG) rather than towards factor VIII clotting activity (VIII:C). Since VIII:C may reside on a separate molecule linked by non convalent bonds to VIIIR:AG, it remains to be demonstrated whether the partial neutralization of VIII:C is specific or secondary to steric hindrance.",

author = "Mannucci, {P. M.} and D. Meyer and Ruggeri, {Z. M.} and J. Koutts and N. Ciavarella and Lavergne, {J. M.}",

year = "1976",

doi = "10.1038/262141a0",

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T1 - Precipitating antibodies in von Willebrand's disease

AU - Mannucci, P. M.

AU - Meyer, D.

AU - Ruggeri, Z. M.

AU - Koutts, J.

AU - Ciavarella, N.

AU - Lavergne, J. M.

PY - 1976

Y1 - 1976

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AB - Precipitating antibodies have been found in 3 polytransfused patients with severe homozygous VWD. Such antibodies seem to be mainly directed towards Willebrand factor and factor VIII related antigen (VIII:AG) rather than towards factor VIII clotting activity (VIII:C). Since VIII:C may reside on a separate molecule linked by non convalent bonds to VIIIR:AG, it remains to be demonstrated whether the partial neutralization of VIII:C is specific or secondary to steric hindrance.

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Precipitating antibodies in von Willebrand's disease

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