Precision medicine in cow's milk allergy: proteomics perspectives from allergens to patients

Enza D'Auria, Chiara Mameli, Cristian Piras, Lucia Cococcioni, Andrea Urbani, Gian Vincenzo Zuccotti, Paola Roncada

Research output: Contribution to journalArticle

Abstract

Cow's milk allergy (CMA) is one of the most common food allergies, especially during childhood. CMA is an immunological mediated adverse reaction to one or more cow's milk proteins, which are normally harmless to a non-allergic individual, as the result of a failure of oral tolerance. To make a correct diagnosis of CMA and a proper treatment is critical in clinical practice. Application of proteomics along with new bio-informatics tools in the field of food allergy is one of the hot topics presented in recent years. In the present review, we focus on recent applications of proteomics to the field of cow's milk allergy, from allergens quantification to the diagnosis, treatment and prognosis. Furthermore, we also shed a light on potential future directions and developments, that are parts of personalized medicine but also of the One Health approach.

SIGNIFICANCE: The field of food allergies is becoming a milestone in public health. Food allergies, in fact, can cause life-threatening reactions and profoundly influence the quality of life. Precise, fast and reliable diagnosis of food allergies, and in particular milk allergies is essential to avoid severe allergic reactions and also to prevent dangerous and eventually unnecessary dietary restrictions; but this can be difficult also due to a complex interaction of genetic background, environment, and microbiota. In this sense, proteomics represents steps toward researching food and milk allergy integrated with the clinic to improve pathophysiology, diagnosis, therapy, and prognosis.

Original languageEnglish
Pages (from-to)173-180
Number of pages8
JournalJournal of Proteomics
Volume188
DOIs
Publication statusPublished - Sep 30 2018

Fingerprint

Milk Hypersensitivity
Allergies
Precision Medicine
Food Hypersensitivity
Proteomics
Allergens
Medicine
Milk Proteins
Microbiota
Computational Biology
Milk
Hypersensitivity
Therapeutics
Public Health
Quality of Life
Public health
Bioinformatics

Cite this

Precision medicine in cow's milk allergy : proteomics perspectives from allergens to patients. / D'Auria, Enza; Mameli, Chiara; Piras, Cristian; Cococcioni, Lucia; Urbani, Andrea; Zuccotti, Gian Vincenzo; Roncada, Paola.

In: Journal of Proteomics, Vol. 188, 30.09.2018, p. 173-180.

Research output: Contribution to journalArticle

D'Auria, Enza ; Mameli, Chiara ; Piras, Cristian ; Cococcioni, Lucia ; Urbani, Andrea ; Zuccotti, Gian Vincenzo ; Roncada, Paola. / Precision medicine in cow's milk allergy : proteomics perspectives from allergens to patients. In: Journal of Proteomics. 2018 ; Vol. 188. pp. 173-180.
@article{7f763775cd474e04ab120b7956d59098,
title = "Precision medicine in cow's milk allergy: proteomics perspectives from allergens to patients",
abstract = "Cow's milk allergy (CMA) is one of the most common food allergies, especially during childhood. CMA is an immunological mediated adverse reaction to one or more cow's milk proteins, which are normally harmless to a non-allergic individual, as the result of a failure of oral tolerance. To make a correct diagnosis of CMA and a proper treatment is critical in clinical practice. Application of proteomics along with new bio-informatics tools in the field of food allergy is one of the hot topics presented in recent years. In the present review, we focus on recent applications of proteomics to the field of cow's milk allergy, from allergens quantification to the diagnosis, treatment and prognosis. Furthermore, we also shed a light on potential future directions and developments, that are parts of personalized medicine but also of the One Health approach.SIGNIFICANCE: The field of food allergies is becoming a milestone in public health. Food allergies, in fact, can cause life-threatening reactions and profoundly influence the quality of life. Precise, fast and reliable diagnosis of food allergies, and in particular milk allergies is essential to avoid severe allergic reactions and also to prevent dangerous and eventually unnecessary dietary restrictions; but this can be difficult also due to a complex interaction of genetic background, environment, and microbiota. In this sense, proteomics represents steps toward researching food and milk allergy integrated with the clinic to improve pathophysiology, diagnosis, therapy, and prognosis.",
author = "Enza D'Auria and Chiara Mameli and Cristian Piras and Lucia Cococcioni and Andrea Urbani and Zuccotti, {Gian Vincenzo} and Paola Roncada",
note = "Copyright {\circledC} 2018 Elsevier B.V. All rights reserved.",
year = "2018",
month = "9",
day = "30",
doi = "10.1016/j.jprot.2018.01.018",
language = "English",
volume = "188",
pages = "173--180",
journal = "Journal of Proteomics",
issn = "1874-3919",
publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Precision medicine in cow's milk allergy

T2 - proteomics perspectives from allergens to patients

AU - D'Auria, Enza

AU - Mameli, Chiara

AU - Piras, Cristian

AU - Cococcioni, Lucia

AU - Urbani, Andrea

AU - Zuccotti, Gian Vincenzo

AU - Roncada, Paola

N1 - Copyright © 2018 Elsevier B.V. All rights reserved.

PY - 2018/9/30

Y1 - 2018/9/30

N2 - Cow's milk allergy (CMA) is one of the most common food allergies, especially during childhood. CMA is an immunological mediated adverse reaction to one or more cow's milk proteins, which are normally harmless to a non-allergic individual, as the result of a failure of oral tolerance. To make a correct diagnosis of CMA and a proper treatment is critical in clinical practice. Application of proteomics along with new bio-informatics tools in the field of food allergy is one of the hot topics presented in recent years. In the present review, we focus on recent applications of proteomics to the field of cow's milk allergy, from allergens quantification to the diagnosis, treatment and prognosis. Furthermore, we also shed a light on potential future directions and developments, that are parts of personalized medicine but also of the One Health approach.SIGNIFICANCE: The field of food allergies is becoming a milestone in public health. Food allergies, in fact, can cause life-threatening reactions and profoundly influence the quality of life. Precise, fast and reliable diagnosis of food allergies, and in particular milk allergies is essential to avoid severe allergic reactions and also to prevent dangerous and eventually unnecessary dietary restrictions; but this can be difficult also due to a complex interaction of genetic background, environment, and microbiota. In this sense, proteomics represents steps toward researching food and milk allergy integrated with the clinic to improve pathophysiology, diagnosis, therapy, and prognosis.

AB - Cow's milk allergy (CMA) is one of the most common food allergies, especially during childhood. CMA is an immunological mediated adverse reaction to one or more cow's milk proteins, which are normally harmless to a non-allergic individual, as the result of a failure of oral tolerance. To make a correct diagnosis of CMA and a proper treatment is critical in clinical practice. Application of proteomics along with new bio-informatics tools in the field of food allergy is one of the hot topics presented in recent years. In the present review, we focus on recent applications of proteomics to the field of cow's milk allergy, from allergens quantification to the diagnosis, treatment and prognosis. Furthermore, we also shed a light on potential future directions and developments, that are parts of personalized medicine but also of the One Health approach.SIGNIFICANCE: The field of food allergies is becoming a milestone in public health. Food allergies, in fact, can cause life-threatening reactions and profoundly influence the quality of life. Precise, fast and reliable diagnosis of food allergies, and in particular milk allergies is essential to avoid severe allergic reactions and also to prevent dangerous and eventually unnecessary dietary restrictions; but this can be difficult also due to a complex interaction of genetic background, environment, and microbiota. In this sense, proteomics represents steps toward researching food and milk allergy integrated with the clinic to improve pathophysiology, diagnosis, therapy, and prognosis.

U2 - 10.1016/j.jprot.2018.01.018

DO - 10.1016/j.jprot.2018.01.018

M3 - Article

C2 - 29408543

VL - 188

SP - 173

EP - 180

JO - Journal of Proteomics

JF - Journal of Proteomics

SN - 1874-3919

ER -