Precision medicine in neuroendocrine neoplasms: An update on current management and future perspectives

Germano Gaudenzi, Alessandra Dicitore, Silvia Carra, Davide Saronni, Carlotta Pozza, Elisa Giannetta, Luca Persani, Giovanni Vitale

Research output: Contribution to journalReview articlepeer-review

Abstract

Neuroendocrine neoplasms (NENs) are traditionally considered as a single group of rare malignancies that originate from the highly spread neuroendocrine system. The clinical management is complex due to the high heterogeneity of these neoplasms in terms of clinical aggressiveness and response to the therapy. Indeed, a multidisciplinary approach is required to reach a personalization of the therapy, including cancer rehabilitation. In this review, we discuss the possibility to adopt a precision medicine (PM) approach in the management of NENs. To this purpose, we summarize current knowledge and future perspectives about biomarkers and preclinical in vitro and in vivo platforms, potentially useful to inform clinicians about the prognosis and for tailoring therapy in patients with NENs. This approach may represent a breakthrough in the therapy and tertiary prevention of these tumors.

Original languageEnglish
Pages (from-to)R1-R10
JournalEuropean Journal of Endocrinology
Volume181
Issue number1
DOIs
Publication statusPublished - Jan 1 2019

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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