Precision medicine into clinical practice: a web‐based tool enables real‐time pharmacogenetic assessment of tailored treatments in psychiatric disorders

Stefania Zampatti, Carlo Fabrizio, Michele Ragazzo, Giulia Campoli, Valerio Caputo, Claudia Strafella, Clelia Pellicano, Raffaella Cascella, Gianfranco Spalletta, Laura Petrosini, Carlo Caltagirone, Andrea Termine, Emiliano Giardina

Research output: Contribution to journalArticlepeer-review

Abstract

The management of neuropsychiatric disorders involves different pharmacological treatments. In order to perform efficacious drug treatments, the metabolism of CYP genes can help to foresee potential drug–drug interactions. The NeuroPGx software is an open‐source web‐based tool for genotype/diplotype/phenotype interpretation for neuropharmacogenomic purposes. The software provides information about: (i) the genotypes of evaluated SNPs (single nucleotide polymorphisms); (ii) the main diplotypes in CYP genes and corresponding metabolization phenotypes; (iii) the list of neuropsychiatric drugs with recommended dosage adjustment (according to CPIC and DPWG guidelines); (iv) the list of possible (rare) diplotypes and corresponding metabolization phenotypes. The combined application of NeuroPGx software to the OpenArray technology results in an easy, quick, and highly automated device ready to be used in routine clinical practice.

Original languageEnglish
Article number851
JournalJournal of Personalized Medicine
Volume11
Issue number9
DOIs
Publication statusPublished - Sep 2021

Keywords

  • NeuroPGx
  • OpenArray
  • Pharmacogenomic
  • Software

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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