Preclinical assessment of volumetric modulated arc therapy for total marrow irradiation

Antonella Fogliata, Luca Cozzi, Alessandro Clivio, Adalberto Ibatici, Pietro Mancosu, Piera Navarria, Giorgia Nicolini, Armando Santoro, Eugenio Vanetti, Marta Scorsetti

Research output: Contribution to journalArticlepeer-review


Purpose: A preclinical investigation was undertaken to explore a treatment technique for total marrow irradiation using RapidArc, a volumetric modulated arc technique. Materials and Methods: Computed tomography datasets of 5 patients were included. Plans with eight overlapping coaxial arcs were optimized for 6-MV photon beams. Dose prescription was 12 Gy in 2 Gy per fraction, normalized so that 100% isodose covered 85% of the planning target volume (PTV). The PTV consisted of the whole skeleton (including ribs and sternum), from the top of the skull to the medium distal third of the femurs. Planning objectives for organs at risk (OARs) were constrained to a median dose

Original languageEnglish
Pages (from-to)628-636
Number of pages9
JournalInternational Journal of Radiation Oncology Biology Physics
Issue number2
Publication statusPublished - Jun 1 2011


  • Intensity-modulated radiotherapy
  • RapidArc
  • Total-marrow irradiation
  • Volumetric modulated arc therapy

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation
  • Cancer Research


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