Aterosclerosis subclinica un indice objetivo de susceptibilidad y riesgo vascular

Translated title of the contribution: Preclinical atherosclerosis. A positive index of increased susceptibility and vascular risk

Jose Pablo Werba, Luis A. Cuniberti, Veronica Martinez, Ricardo H. Rey

Research output: Contribution to journalArticlepeer-review

Abstract

Clinical data suggest that the individual susceptibility to atherosclerosis is not accounted for only by exposure to classical or "emerging" vascular risk factors. Although recent investigations with transgenic animals have revealed new genetic determinants of susceptibility, little is known concerning this situation in human beings. Even though the human genoma project might uncover specific genetic markers in the future, the only early and objective method to identify the susceptible individual at present is to detect atherosclerosis non-invasively. High resolution B-mode ultrasonography of superficial arteries coupled with advanced computer-assisted image processing systems is a highly reproducible method to perform a quali-quantitative early evaluation of already developed wall lesions. Clinically more significant, the detection of silent atherosclerosis has an additional value for risk factor assessment in the prediction of global vascular risk, a relevant index for decision-making in cardiovascular prevention. It is conceivable that the introduction of non-invasive measures of the atherosclerotic burden in risk stratification of asymptomatic subjects will help to target interventions for more rational risk factor control and to reduce the cost/benefit ratio of primary prevention.

Translated title of the contributionPreclinical atherosclerosis. A positive index of increased susceptibility and vascular risk
Original languageSpanish
Pages (from-to)382-384
Number of pages3
JournalMedicina
Volume59
Issue number4
Publication statusPublished - 1999

Keywords

  • Atherosclerosis
  • B-mode ultrasonography

ASJC Scopus subject areas

  • Medicine(all)

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