Preclinical evaluation of injectable bone substitute materials

Matilde Bongio, Jeroen J J P van den Beucken, Sander C G Leeuwenburgh, John A. Jansen

Research output: Contribution to journalArticle

Abstract

Injectable bone substitutes (IBSs) represent an attractive class of ready-to-use biomaterials, both ceramic- and polymer-based, as they offer the potential benefit of minimally invasive surgery and optimal defect filling. Although in vitro assessments are the first step in the process of development, the safety and efficacy of an IBS strongly depend on validated preclinical research prior to clinical trials. However, the selection of a suitable preclinical model for performance evaluation of an IBS remains a challenge, as no gold standard exists to define the best animal model. In order to succeed in this attempt, we identified three stages of development, including (a) proof-of-principle, (b) predictive validity and (c) general scientific legitimacy, and the respective criteria that should be applied for such selection. The second part of this review provides an overview of commonly used animals for IBSs. Specifically, scientific papers published between January 1996 and March 2012 were retrieved that report the use of preclinical models for the evaluation of IBSs in situations requiring bone healing and bone augmentation. This review is meant not only to describe the currently available preclinical models for IBS application, but also to address critical considerations of such multi-factorial evaluation models (including animal species, strain, age, anatomical site, defect size and type of bone), which can be indicative but in most cases edge away from the human reality. Consequently, the ultimate goal is to guide researchers toward a more careful and meaningful interpretation of the results of experiments using animal models and their clinical applications.

Original languageEnglish
Pages (from-to)191-209
Number of pages19
JournalJournal of Tissue Engineering and Regenerative Medicine
Volume9
Issue number3
DOIs
Publication statusPublished - Mar 1 2015

Keywords

  • Animal models
  • Bone augmentation
  • Bone defect
  • Bone substitutes
  • Ceramic-based biomaterials
  • Hydrogel-based biomaterials
  • Injectable
  • Preclinical studies

ASJC Scopus subject areas

  • Biomedical Engineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Medicine(all)

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  • Cite this

    Bongio, M., van den Beucken, J. J. J. P., Leeuwenburgh, S. C. G., & Jansen, J. A. (2015). Preclinical evaluation of injectable bone substitute materials. Journal of Tissue Engineering and Regenerative Medicine, 9(3), 191-209. https://doi.org/10.1002/term.1637