Preclinical imaging for the study of mouse models of thyroid cancer

Adelaide Greco, Luigi Auletta, Francesca Maria Orlandella, Paola Lucia Chiara Iervolino, Michele Klain, Giuliana Salvatore, Marcello Mancini

Research output: Contribution to journalReview article

Abstract

Thyroid cancer, which represents the most common tumors among endocrine malignancies, comprises a wide range of neoplasms with different clinical aggressiveness. One of the most important challenges in research is to identify mouse models that most closely resemble human pathology; other goals include finding a way to detect markers of disease that common to humans and mice and to identify the most appropriate and least invasive therapeutic strategies for specific tumor types. Preclinical thyroid imaging includes a wide range of techniques that allow for morphological and functional characterization of thyroid disease as well as targeting and in most cases, this imaging allows quantitative analysis of the molecular pattern of the thyroid cancer. The aim of this review paper is to provide an overview of all of the imaging techniques used to date both for diagnosis and theranostic purposes in mouse models of thyroid cancer.

Original languageEnglish
Article number2731
JournalInternational Journal of Molecular Sciences
Volume18
Issue number12
DOIs
Publication statusPublished - Dec 16 2017

Keywords

  • Mouse models
  • Nuclear medicine
  • Preclinical imaging
  • Theranostic
  • Thyroid cancer
  • Ultrasound

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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